{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T01:49:43Z","timestamp":1793238583100,"version":"4.5.0"},"reference-count":0,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1986,7,1]]},"abstract":"<jats:p> Lengthening (eccentric) contractions result in injury to skeletal muscle fibers. Two hypotheses were tested through lengthening contractions of an in situ muscle preparation: the extent of injury increases with increases in the duration; and the extent of injury increases with increases in the peak force. Mice were anesthetized, and distal tendons of the extensor digitorum longus muscles were attached to a servomotor. Muscles were stimulated at 150 Hz and lengthened 20% of fiber length (Lf). Lengthening contractions were performed at 0.2, 0.5, or 1.0 Lf\/s with durations of 0.5\u201315 min. Peak force during lengthening contractions at 1.0 Lf\/s was decreased by inducing fatigue with isometric contractions, stimulating at 70\u2013100 Hz, or 3) lengthening 10% of Lf. Injury was assessed 3 days after lengthening contractions by histological appearance and maximum force (Po) development. Injury increased with duration up to 5 min. After 5 min, fatigue appeared to prevent further injury. Results for 0.2 and 0.5 Lf\/s were similar to those for 1.0 Lf\/s but with less injury. A high correlation was observed between histological appearance of injury and the decrease in Po. The extent of injury was related to the peak force developed during the lengthening contractions. <\/jats:p>","DOI":"10.1152\/jappl.1986.61.1.293","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T05:41:57Z","timestamp":1513834917000},"page":"293-299","source":"Crossref","is-referenced-by-count":185,"title":["Characteristics of lengthening contractions associated with injury to skeletal muscle fibers"],"prefix":"10.1152","volume":"61","author":[{"given":"K. K.","family":"McCully","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Faulkner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1986.61.1.293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T10:53:38Z","timestamp":1567940018000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1986.61.1.293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1986,7,1]]}},"alternative-id":["10.1152\/jappl.1986.61.1.293"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1986.61.1.293","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,7,1]]}}}