{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T17:08:29Z","timestamp":1776186509143,"version":"3.50.1"},"reference-count":0,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1986,9,1]]},"abstract":"<jats:p> We investigated whether neutrophil suppression would prevent the early hyperoxic injury to the rabbit alveolar epithelium. Rabbits received a single intravenous injection of either nitrogen mustard (2 mg\/kg) or saline and were exposed to 100% C2 for 64 h. At the end of the hyperoxic exposure, there were 20 +\/- 7 neutrophils\/ml blood in the nitrogen mustard group vs. 5,935 +\/- 1,174 in the control group (means +\/- SE; P less than 0.05). The corresponding numbers in lung extravascular tissue, expressed per high-power field, were 0.37 +\/- 7 and 5.9 +\/- 0.35, respectively (P less than 0.05). At this time, the rate constants of solute flux for 57Co-vitamin B12 (r = 6.5 A) and 131I-cytochrome c (r = 17 A), across the alveolar epithelium, were 33 +\/- 5 (min-1) and 7 +\/- 2 for the nitrogen mustard and 29 +\/- 5 and 6 +\/- 1 for the saline group, respectively. These variables were ninefold higher than their corresponding values in animals breathing air. We concluded that neutrophils do not play a significant role during the early stages of sublethal hyperoxic injury to rabbit alveolar epithelium. <\/jats:p>","DOI":"10.1152\/jappl.1986.61.3.1126","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T05:33:18Z","timestamp":1513834398000},"page":"1126-1131","source":"Crossref","is-referenced-by-count":24,"title":["Effects of hyperoxia on alveolar permeability of neutropenic rabbits"],"prefix":"10.1152","volume":"61","author":[{"given":"M. J.","family":"Laughlin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Wild","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. A.","family":"Nickerson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Matalon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1986.61.3.1126","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T10:54:12Z","timestamp":1567940052000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1986.61.3.1126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1986,9,1]]}},"alternative-id":["10.1152\/jappl.1986.61.3.1126"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1986.61.3.1126","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,9,1]]}}}