{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:03:59Z","timestamp":1789470239475,"version":"build-2803163510"},"reference-count":0,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1986,11,1]]},"abstract":"<jats:p> The objective of this study was to determine whether arterial PCO2 (PaCO2) decreases or remains unchanged from resting levels during mild to moderate steady-state exercise in the dog. To accomplish this, O2 consumption (VO2) arterial blood gases and acid-base status, arterial lactate concentration ([LA-]a), and rectal temperature (Tr) were measured in 27 chronically instrumented dogs at rest, during different levels of submaximal exercise, and during maximal exercise on a motor-driven treadmill. During mild exercise [35% of maximal O2 consumption (VO2 max)], PaCO2 decreased 5.3 +\/- 0.4 Torr and resulted in a respiratory alkalosis (delta pHa = +0.029 +\/- 0.005). Arterial PO2 (PaO2) increased 5.9 +\/- 1.5 Torr and Tr increased 0.5 +\/- 0.1 degree C. As the exercise levels progressed from mild to moderate exercise (64% of VO2 max) the magnitude of the hypocapnia and the resultant respiratory alkalosis remained unchanged as PaCO2 remained 5.9 +\/- 0.7 Torr below and delta pHa remained 0.029 +\/- 0.008 above resting values. When the exercise work rate was increased to elicit VO2 max (96 +\/- 2 ml X kg-1 X min-1) the amount of hypocapnia again remained unchanged from submaximal exercise levels and PaCO2 remained 6.0 +\/- 0.6 Torr below resting values; however, this response occurred despite continued increases in Tr (delta Tr = 1.7 +\/- 0.1 degree C), significant increases in [LA-]a (delta [LA-]a = 2.5 +\/- 0.4), and a resultant metabolic acidosis (delta pHa = -0.031 +\/- 0.011). The dog, like other nonhuman vertebrates, responded to mild and moderate steady-state exercise with a significant hyperventilation and respiratory alkalosis.(ABSTRACT TRUNCATED AT 250 WORDS) <\/jats:p>","DOI":"10.1152\/jappl.1986.61.5.1914","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T11:30:57Z","timestamp":1513855857000},"page":"1914-1919","source":"Crossref","is-referenced-by-count":22,"title":["Arterial blood gases and acid-base status of dogs during graded dynamic exercise"],"prefix":"10.1152","volume":"61","author":[{"given":"T. I.","family":"Musch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. B.","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. C.","family":"Haidet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Stray-Gundersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. G.","family":"Waldrop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. A.","family":"Ordway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1986.61.5.1914","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T15:03:53Z","timestamp":1567955033000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1986.61.5.1914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,11,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1986,11,1]]}},"alternative-id":["10.1152\/jappl.1986.61.5.1914"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1986.61.5.1914","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,11,1]]}}}