{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T00:40:11Z","timestamp":1698453611002},"reference-count":0,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1986,12,1]]},"abstract":"<jats:p> We assessed pulmonary endothelial and epithelial permeability and lung lymph flow in nine adult sheep under base-line conditions and after resuscitation from profound hemorrhagic shock. Animals were mechanically ventilated and maintained on 1% halothane anesthesia while aortic pressure was held at 40 Torr for 3 h. Systemic heparin was not used. After reinfusion of shed blood, sheep recovered from anesthesia and we measured lung lymph flow (QL), lymph-to-plasma concentration ratio for proteins, and time taken to reach half-equilibrium concentration of intravenous tracer albumin in lymph (t1\/2). Twenty-four hours after bolus injection of radio-albumin we lavaged subsegments of the right upper lobe and determined fractional equilibration of the tracer in the alveolar luminal-lining layer. In each sheep we had measured these parameters 7 days earlier under base-line conditions. Animals were killed, and the lungs were used for gravimetric determination of extravascular lung water (gravimetric extravascular lung water-to-dry weight ratio) 24 h after resuscitation from shock. Pulmonary endothelial injury after resuscitation was evidenced by marked increase in QL, without fall in lymph-to-plasma ratio. Time taken to reach half-equilibrium concentration fell from 169 +\/- 47 (SD) min in base-line studies to 53 +\/- 33 min after shock. There was no evidence of lung epithelial injury. Gravimetric extravascular lung water-to-dry weight ratio was significantly increased in these animals killed 24 h after resuscitation (4.94 +\/- 0.29) compared with values in our laboratory controls (4.13 +\/- 0.09, mean +\/- SD). These data demonstrate a loss of lung endothelial integrity in sheep after resuscitation from profound hemorrhagic shock. <\/jats:p>","DOI":"10.1152\/jappl.1986.61.6.2156","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T11:13:14Z","timestamp":1513854794000},"page":"2156-2161","source":"Crossref","is-referenced-by-count":5,"title":["Permeability of barriers to albumin flux in lungs of sheep resuscitated from hemorrhagic shock"],"prefix":"10.1152","volume":"61","author":[{"given":"A. B.","family":"Gorin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Mendiondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1986.61.6.2156","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T15:00:20Z","timestamp":1567954820000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1986.61.6.2156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1986,12,1]]}},"alternative-id":["10.1152\/jappl.1986.61.6.2156"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1986.61.6.2156","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,12,1]]}}}