{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T11:40:52Z","timestamp":1693222852621},"reference-count":0,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1987,6,1]]},"abstract":"<jats:p> Intravenous infusion of Hacetate in conscious rabbits induces a greater decrease in cerebrospinal fluid (CSF) [HCO3-] and arterial CO2 partial pressure (PaCO2) than does HCl, HNO3, or Hacetate. To test whether acetate per se can stimulate central chemoreceptors, HCl- or Hacetate-acidified mock CSF was infused via the cisterna magna in conscious rabbits with catheters preimplanted under anesthesia. HCl infusion induced a greater decrease in PaCO2 refuting this hypothesis. To evaluate the role of the carotid body HCl and Hacetate were infused intravenously in an intact (CB+) and a chemodenervated group (CB-). In CB+ rabbits Hacetate infusion produced a greater decrease in PaCO2. In CB- rabbits, the fractional decrease in arterial PaCO2 was less for both acids compared with that of the CB+ rabbits, but it was significantly greater for Hacetate infusion (21.2 +\/- 2.5%, mean +\/- SE) than for HCl infusion (14.5 +\/- 1.8%). Thus the carotid body is not necessary for the greater Hacetate ventilatory stimulation. The working hypothesis is that nonionic diffusion of Hacetate into brain or acetate replacement of HCO3- in CSF production lowers [HCO3-] near central chemoreceptors. <\/jats:p>","DOI":"10.1152\/jappl.1987.62.6.2154","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T11:52:36Z","timestamp":1513857156000},"page":"2154-2159","source":"Crossref","is-referenced-by-count":2,"title":["Central vs. peripheral chemoreceptors in ventilatory stimulation by Hacetate"],"prefix":"10.1152","volume":"62","author":[{"given":"E. E.","family":"Nattie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1987.62.6.2154","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T15:04:39Z","timestamp":1567955079000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1987.62.6.2154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1987,6,1]]}},"alternative-id":["10.1152\/jappl.1987.62.6.2154"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1987.62.6.2154","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,6,1]]}}}