{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T14:07:36Z","timestamp":1773756456357,"version":"3.50.1"},"reference-count":0,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1987,9,1]]},"abstract":"<jats:p> To determine the sensory receptor of the nonadrenergic inhibitory nervous system (NAIS), 22 cats were anesthetized and serotonin was continuously administered (50\u2013250 micrograms.kg-1.min-1 iv) to increase pulmonary resistance (RL) to 377 +\/- 57% (SE) of the control value. We then 1) mechanically irritated the trachea, 2) intravenously administered capsaicin (5 micrograms\/kg), or 3) induced hypoxia (arterial PO2 30\u201340 Torr) to stimulate irritant and bronchial C-fiber receptors, pulmonary C-fiber receptors, or the carotid body (chemoreceptors), respectively. After treatment with atropine (3 mg\/kg iv) and propranolol (2 mg\/kg iv), the serotonin-induced change in RL was reduced by 58.6 +\/- 14.3% by mechanical irritation and 63.3 +\/- 12.1% by intravenous capsaicin. However, hypoxia produced no dilatation of the airways. In further experiments, we employed capsaicin inhalation to stimulate bronchial C-fiber receptors. Inhaled capsaicin (0.1%, for 5 breaths) also reduced RL by 79.2 +\/- 9.2% of the elevated value, after atropine and propranolol. Treatment with a ganglionic blocking agent, hexamethonium (2 mg\/kg iv), abolished bronchodilator responses, implying that a reflex pathway through vagal nerves is involved in this phenomenon. These results suggest that pulmonary and bronchial C-fiber receptors may be involved as sensory receptors in NAIS reflex bronchodilatation. <\/jats:p>","DOI":"10.1152\/jappl.1987.63.3.923","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T20:04:55Z","timestamp":1513886695000},"page":"923-929","source":"Crossref","is-referenced-by-count":39,"title":["Possible sensory receptor of nonadrenergic inhibitory nervous system"],"prefix":"10.1152","volume":"63","author":[{"given":"M.","family":"Ichinose","sequence":"first","affiliation":[{"name":"First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Inoue","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Miura","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Yafuso","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Nogami","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Takishima","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1987.63.3.923","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T15:58:36Z","timestamp":1567958316000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1987.63.3.923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1987,9,1]]}},"alternative-id":["10.1152\/jappl.1987.63.3.923"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1987.63.3.923","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,9,1]]}}}