{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T16:49:29Z","timestamp":1770223769760,"version":"3.49.0"},"reference-count":0,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1987,11,1]]},"abstract":"<jats:p> Interleukin-1 (IL-1) mediates components of the acute phase response, stimulates granulocyte metabolism, and induces endothelial cell surface changes. We studied in unanesthetized rabbits the effects of intravenous divided dose infusions of a murine monokine preparation containing IL-1 activity, on circulating granulocytes, their sequestration within the pulmonary microvasculature, pulmonary edema formation, and changes in pulmonary vascular permeability. Monokine administration induced significant (P less than 0.01) granulocytopenia as well as a significant (P less than 0.001) increase in mean alveolar septal wall granulocytes per high power field (HPF) compared with saline-injected controls. Infusions of the monokine preparation significantly (P less than 0.005) increased lung wet-to-dry weight ratios as well as significantly (P less than 0.025) increased pulmonary extravasation of radiolabeled albumin. Electron microscopic analysis of lung sections obtained from monokine-infused animals demonstrated endothelial injury, perivascular edema, and extravasation of an ultrastructural tracer. We conclude that a monokine preparation containing IL-1 activity can induce profound granulocytopenia, pulmonary leukostasis, and acute pulmonary vascular endothelial injury. <\/jats:p>","DOI":"10.1152\/jappl.1987.63.5.2093","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T19:32:55Z","timestamp":1513884775000},"page":"2093-2100","source":"Crossref","is-referenced-by-count":32,"title":["Monokine-induced acute lung injury in rabbits"],"prefix":"10.1152","volume":"63","author":[{"given":"S. E.","family":"Goldblum","sequence":"first","affiliation":[{"name":"Department of Medicine, Veterans Administration Medical Center, Lexington, Kentucky."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Jay","sequence":"additional","affiliation":[{"name":"Department of Medicine, Veterans Administration Medical Center, Lexington, Kentucky."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Yoneda","sequence":"additional","affiliation":[{"name":"Department of Medicine, Veterans Administration Medical Center, Lexington, Kentucky."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. A.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Veterans Administration Medical Center, Lexington, Kentucky."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. J.","family":"McClain","sequence":"additional","affiliation":[{"name":"Department of Medicine, Veterans Administration Medical Center, Lexington, Kentucky."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. N.","family":"Gillespie","sequence":"additional","affiliation":[{"name":"Department of Medicine, Veterans Administration Medical Center, Lexington, Kentucky."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1987.63.5.2093","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T15:55:53Z","timestamp":1567958153000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1987.63.5.2093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,11,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1987,11,1]]}},"alternative-id":["10.1152\/jappl.1987.63.5.2093"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1987.63.5.2093","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,11,1]]}}}