{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T08:03:44Z","timestamp":1745049824188},"reference-count":0,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1987,12,1]]},"abstract":"<jats:p> We examined the respiratory effects of a patent ductus arteriosus in 29 premature lambs (131\u2013135 days gestational age) after infiltrating the ductal wall with formaldehyde solution (Formalin) and placing a snare around the ductus to regulate its patency. The lambs were given sheep surfactant, paralyzed, and mechanically ventilated at birth. We first compared 8 lambs with open ductus and 13 lambs with closed ductus during the 12 h after birth. Although lambs with open ductus had greater pulmonary blood flow (301 +\/- 36 vs. 188 +\/- 11 ml.min-1.kg-1, mean +\/- SE, at 12 h of age) and mean pulmonary arterial (44 +\/- 3 vs. 33 +\/- 2 mmHg) and left ventricular end-diastolic (6 +\/- 0.6 vs 4 +\/- 0.7 mmHg) pressures, we found no differences in dynamic respiratory compliance (Cdyn = 0.55 +\/- 0.07 vs. 0.55 +\/- 0.03 ml.cmH2O\u20131.kg-1), midtidal volume resistance (62 +\/- 5 X 10(-3) vs. 62 +\/- 7 X 10(-3) cmH2O.ml-1.s), or functional residual capacity (FRC = 27 +\/- 3 vs. 26 +\/- 2 ml.kg-1). Alveolar-arterial PO2 difference was lower in the lambs with open ductus (238 +\/- 65 vs. 362 +\/- 37 Torr). Next, we challenged eight lambs with two separate saline infusions (50 ml.kg-1 over 3 min), each given with the ductus alternately closed or open. When the ductus was closed, FRC was unchanged, but Cdyn increased by 18% immediately after the infusion. When the ductus was open, FRC decreased by 16% and Cdyn decreased by 12%. We conclude that the premature lamb is surprisingly resistant to changes in respiratory function from ductal patency during the immediate neonatal period. <\/jats:p>","DOI":"10.1152\/jappl.1987.63.6.2315","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T21:09:36Z","timestamp":1513890576000},"page":"2315-2324","source":"Crossref","is-referenced-by-count":30,"title":["Respiratory effects of a patent ductus arteriosus in premature newborn lambs"],"prefix":"10.1152","volume":"63","author":[{"given":"J. J.","family":"Perez Fontan","sequence":"first","affiliation":[{"name":"Cardiovascular Research Institute, University of California, San Francisco."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. I.","family":"Clyman","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, University of California, San Francisco."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Mauray","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, University of California, San Francisco."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A.","family":"Heymann","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, University of California, San Francisco."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Roman","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, University of California, San Francisco."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1987.63.6.2315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T16:06:19Z","timestamp":1567958779000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1987.63.6.2315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1987,12,1]]}},"alternative-id":["10.1152\/jappl.1987.63.6.2315"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1987.63.6.2315","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,12,1]]}}}