{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T01:56:02Z","timestamp":1781920562005,"version":"3.54.5"},"reference-count":0,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1987,12,1]]},"abstract":"<jats:p> Central venous pressure (CVP) was measured in 14 males during 23.3 +\/- 0.6 s (mean +\/- SE) of weightlessness (0.00 +\/- 0.05 G) achieved in a Gulfstream-3 jet aircraft performing parabolic flight maneuvers and during either 60 or 120 s of +2 Gz (2.0 +\/- 0.1 Gz). CVP was obtained using central venous catheters and strain-gauge pressure transducers. Heart rate (HR) was measured simultaneously in seven of the subjects. Measurements were compared with values obtained inflight at 1 G with the subjects in the supine (+1 Gx) and upright sitting (+1 Gz) positions, respectively. CVP was 2.6 +\/- 1.5 mmHg during upright sitting and 5.0 +\/- 0.7 mmHg in the supine position. During weightlessness, CVP increased significantly to 6.8 +\/- 0.8 mmHg (P less than 0.005 compared with both upright sitting and supine inflight). During +2 Gz, CVP was 2.8 +\/- 1.4 mmHg and only significantly lower than CVP during weightlessness (P less than 0.05). HR increased from 65 +\/- 7 beats\/min at supine and 70 +\/- 5 beats\/min during upright sitting to 79 +\/- 7 beats\/min (P less than 0.01 compared with supine) during weightlessness and to 80 +\/- 6 beats\/min (P less than 0.01 compared with upright sitting and P less than 0.001 compared with supine) during +2 Gz. We conclude that the immediate onset of weightlessness induces a significant increase in CVP, not only compared with the upright sitting position but also compared with the supine position at 1 G. <\/jats:p>","DOI":"10.1152\/jappl.1987.63.6.2433","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T21:09:36Z","timestamp":1513890576000},"page":"2433-2437","source":"Crossref","is-referenced-by-count":38,"title":["Central venous pressure in humans during short periods of weightlessness"],"prefix":"10.1152","volume":"63","author":[{"given":"P.","family":"Norsk","sequence":"first","affiliation":[{"name":"Institute of Aerospace Medicine, University Hospital, Copenhagen, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Foldager","sequence":"additional","affiliation":[{"name":"Institute of Aerospace Medicine, University Hospital, Copenhagen, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Bonde-Petersen","sequence":"additional","affiliation":[{"name":"Institute of Aerospace Medicine, University Hospital, Copenhagen, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Elmann-Larsen","sequence":"additional","affiliation":[{"name":"Institute of Aerospace Medicine, University Hospital, Copenhagen, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. S.","family":"Johansen","sequence":"additional","affiliation":[{"name":"Institute of Aerospace Medicine, University Hospital, Copenhagen, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1987.63.6.2433","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T16:06:28Z","timestamp":1567958788000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1987.63.6.2433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1987,12,1]]}},"alternative-id":["10.1152\/jappl.1987.63.6.2433"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1987.63.6.2433","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,12,1]]}}}