{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T22:52:12Z","timestamp":1771627932144,"version":"3.50.1"},"reference-count":0,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1989,2,1]]},"abstract":"<jats:p> Hyperoxia affects O2 chemoreception in the highly perfused carotid bodies and causes a reduction of the ventilatory hypoxic drive (HD) as was shown for anesthetized cats and awake rats. We looked for a quantitative description of such an effect on HD as a function of both O2 pressure and exposure duration. Ventilation of rats was measured using the barometric method before and after hyperbaric O2 (HBO) exposure, at either air, 80% O2, or 4% O2. We used three exposure durations: 180, 550 and 900 min. The O2 pressure ranged between 1.2 and 3.0 ATA. At each time duration we used four to five groups of rats at a range of O2 pressures that yielded the full scale of effect on HD but avoided obvious lasting difficulties in breathing. HBO caused a reduction of breathing frequency and elevation of tidal volume in both air and 80% O2 but almost no change in minute ventilation. Hypoxic minute ventilation (4% O2) decreased after HBO, mainly through reduced frequency. HD was described by a power function of O2 pressure for each HBO duration. HD did not decline below 20% of the full control response. Ventilatory HD diminution is pictured as a function of both O2 pressure and HBO duration. The dependency of HD on exposure time and on pressure is similar to other known toxic effects of HBO. <\/jats:p>","DOI":"10.1152\/jappl.1989.66.2.851","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T14:33:47Z","timestamp":1513866827000},"page":"851-856","source":"Crossref","is-referenced-by-count":15,"title":["Attenuation of hypoxic ventilation by hyperbaric O2: effects of pressure and exposure time"],"prefix":"10.1152","volume":"66","author":[{"given":"I.","family":"Liberzon","sequence":"first","affiliation":[{"name":"Israel Naval Hyperbaric Institute, Haifa."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Arieli","sequence":"additional","affiliation":[{"name":"Israel Naval Hyperbaric Institute, Haifa."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Kerem","sequence":"additional","affiliation":[{"name":"Israel Naval Hyperbaric Institute, Haifa."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1989.66.2.851","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T15:32:02Z","timestamp":1567956722000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1989.66.2.851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1989,2,1]]}},"alternative-id":["10.1152\/jappl.1989.66.2.851"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1989.66.2.851","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,2,1]]}}}