{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T21:23:00Z","timestamp":1649107380922},"reference-count":0,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1989,5,1]]},"abstract":"<jats:p> Increases in brain stem blood flow (BBF) during hypoxia may decrease tissue PCO2\/[H+], causing minute ventilation (VE) to decrease. To determine whether an increase in BBF, isolated from changes in arterial PO2 and PCO2, can affect respiration, we obstructed the thoracic aorta with a balloon in 31 intact and 24 peripherally chemobarodenervated, anesthetized, spontaneously breathing newborn piglets. Continuous measurements of cardiorespiratory variables were made before and during 2 min of aortic obstruction. Radiolabeled microspheres were used to measure BBF before and approximately 30 s after balloon inflation in eight intact and five denervated animals. After balloon inflation, there was a rapid increase in mean blood pressure in both the intact and denervated animals, followed within 10 s by a decrease in tidal volume and VE. In the intact animals, the decrease in VE after acute hypertension can be ascribed to a baroreceptor-mediated reflex. After peripheral chemobarodenervation, however, acute hypertension continued to produce a decrease in VE, which cannot be explained by baroreceptor stimulation. In these denervated animals, aortic balloon inflation was associated with an increase in BBF (13.1 +\/- 2.7%; P less than 0.05). We speculate that the increase in BBF during hypoxia may contribute to the decrease in ventilation observed after carotid body denervation. <\/jats:p>","DOI":"10.1152\/jappl.1989.66.5.2174","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T14:05:19Z","timestamp":1513865119000},"page":"2174-2180","source":"Crossref","is-referenced-by-count":3,"title":["Effect of aortic balloon inflation on ventilation and brain stem blood flow in piglets"],"prefix":"10.1152","volume":"66","author":[{"given":"G. A.","family":"Green","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Virginia School of Medicine, Charlottesville 22908."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. A.","family":"Darnall","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Virginia School of Medicine, Charlottesville 22908."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. B.","family":"Bierd","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Virginia School of Medicine, Charlottesville 22908."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Adams","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Virginia School of Medicine, Charlottesville 22908."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1989.66.5.2174","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T15:29:26Z","timestamp":1567956566000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1989.66.5.2174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1989,5,1]]}},"alternative-id":["10.1152\/jappl.1989.66.5.2174"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1989.66.5.2174","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,5,1]]}}}