{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:36:03Z","timestamp":1756992963804},"reference-count":0,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1989,7,1]]},"abstract":"<jats:p> The phenomenon of contractile agonist-dependent relaxation by isoproterenol (ISO) of active tension elicited by acetylcholine (ACh), histamine (HIS), serotonin (5-HT), and potassium chloride-substituted Krebs-Henseleit solution (KCl) was studied in 210 tracheal smooth muscle (TSM) strips from 28 mongrel dogs in vitro. All TSM strips were contracted to similar active tensions [target tension (TT) = 50% of the maximal active tension elicited by 127 mM KCl] with ACh, HIS, 5-HT, or KCl and relaxed with either ISO, forskolin (FSK), N6,2\u2032-O-dibutyryladenosine 3\u2032,5\u2032-cyclic monophosphate (db-cAMP), or 3-isobutyl-1-methylxanthine (IMX). The concentrations of ISO causing 50% relaxation from TT (RC50) were ACh (2.9 +\/- 1.1 x 10(-6) M) greater than 5-HT (8.4 +\/- 1.5 x 10(-8) M) approximately KCl (8.1 +\/- 2.1 x 10(-8) M) greater than HIS (1.6 +\/- 0.2 x 10(-8) M). FSK and IMX relaxed TSM in the same rank order of potency as ISO. In contrast to the contractile agonist-dependent relaxation elicited by ISO, FSK, and IMX, db-cAMP was nearly equipotent in relaxing similarly contracted strips. These results are consistent with contractile agonist-specific interaction with cAMP production by ISO and FSK. These data demonstrate that the phenomenon of contractile agonist-dependent relaxation by ISO is not related specifically to the beta-adrenoceptor. <\/jats:p>","DOI":"10.1152\/jappl.1989.67.1.181","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T16:22:20Z","timestamp":1513873340000},"page":"181-185","source":"Crossref","is-referenced-by-count":8,"title":["Beta-adrenergic relaxation of dog trachealis: contractile agonist-specific interaction"],"prefix":"10.1152","volume":"67","author":[{"given":"S. M.","family":"Koenig","sequence":"first","affiliation":[{"name":"Division of Biological Sciences, University of Chicago, Illinois 60637."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. W.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Division of Biological Sciences, University of Chicago, Illinois 60637."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Division of Biological Sciences, University of Chicago, Illinois 60637."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. R.","family":"White","sequence":"additional","affiliation":[{"name":"Division of Biological Sciences, University of Chicago, Illinois 60637."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. R.","family":"Leff","sequence":"additional","affiliation":[{"name":"Division of Biological Sciences, University of Chicago, Illinois 60637."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. J.","family":"Popovich","sequence":"additional","affiliation":[{"name":"Division of Biological Sciences, University of Chicago, Illinois 60637."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1989.67.1.181","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T15:40:40Z","timestamp":1567957240000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1989.67.1.181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1989,7,1]]}},"alternative-id":["10.1152\/jappl.1989.67.1.181"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1989.67.1.181","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,7,1]]}}}