{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T03:39:18Z","timestamp":1773459558905,"version":"3.50.1"},"reference-count":0,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1989,7,1]]},"abstract":"<jats:p> The effects of low O2 on glucose consumption in the rabbit carotid body were studied using the in vitro 2-deoxyglucose technique. Metabolically active structures within the tissue were localized autoradiographically after freeze-drying and vacuum fixation\/embedding of selected incubated tissue samples. In 100% O2-equilibrated media, the mean basal glucose consumption calculated from the rate of 2-[1,2\u20133H]deoxy-D-glucose phosphorylation and its specific activity in the incubation media was 61 nmol.g tissue-1.min-1 in the carotid body and 42 nmol.g tissue-1.min-1 in parallel experiments with nodose ganglia. Low PO2 (20% O2-equilibrated media in vitro) increased glucose consumption in the carotid body by 44% but did not alter glucose metabolism of nodose ganglia. Autoradiographic data showed that preneural type I parenchymal cells are the principal site of glucose consumption in carotid chemosensory tissue. The mechanisms responsible for the hypoxia-induced increase in glucose consumption by the type I cells are discussed in relation to sensory transduction by the carotid body chemoreceptors. <\/jats:p>","DOI":"10.1152\/jappl.1989.67.1.484","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T11:22:20Z","timestamp":1513855340000},"page":"484-487","source":"Crossref","is-referenced-by-count":15,"title":["Metabolic activation of carotid body glomus cells by hypoxia"],"prefix":"10.1152","volume":"67","author":[{"given":"A.","family":"Obeso","sequence":"first","affiliation":[{"name":"Department of Physiology, University of Utah School of Medicine, Salt Lake City 84108."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Utah School of Medicine, Salt Lake City 84108."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Dinger","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Utah School of Medicine, Salt Lake City 84108."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Fidone","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Utah School of Medicine, Salt Lake City 84108."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1989.67.1.484","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T11:41:28Z","timestamp":1567942888000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1989.67.1.484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1989,7,1]]}},"alternative-id":["10.1152\/jappl.1989.67.1.484"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1989.67.1.484","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,7,1]]}}}