{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T22:44:14Z","timestamp":1771627454633,"version":"3.50.1"},"reference-count":0,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1990,4,1]]},"abstract":"<jats:p> This study investigated the role of adenosine in the regulation of neonatal cerebral blood flow (CBF) during moderate (arterial PO2 = 47 +\/- 9 Torr) and severe (arterial PO2 = 25 +\/- 4 Torr) hypoxia. Twenty-eight anesthetized and ventilated newborn piglets were assigned to four groups: 8 were injected intravenously with the vehicle (controls, group 1); 13 received an intravenous injection of 8-phenyltheophylline (8-PT), a potent adenosine receptor blocker, either 4 mg\/kg (group 2, n = 6, mean cerebrospinal fluid (CSF) levels less than 1 mg\/l) or 8 mg\/kg (group 3, n = 7, mean CSF levels less than 3.5 mg\/l); and 7 received an intracerebroventricular injection of 10 micrograms 8-PT (group 4). During normoxia, CBF was not altered by vehicle or 8-PT injections. In group 1, 10 min of moderate and severe hypoxia increased total CBF by 112 +\/- 36 and 176 +\/- 28% (SE), respectively. Compared with controls, the cerebral hyperemia during moderate hypoxia was not altered in group 2, attenuated in group 3 (to 53 +\/- 13%, P = NS), and completely blocked in group 4 (P less than 0.01). CBF increase secondary to severe hypoxia was attenuated only in group 4 (74 +\/- 29%, P less than 0.05). CSF concentrations of adenosine and adenosine metabolites measured by high-performance liquid chromatography increased during hypoxia. Arterial O2 content was inversely correlated (P less than 0.005) to maximal CSF levels of adenosine (r = 0.73), inosine (r = 0.87), and hypoxanthine (r = 0.80).(ABSTRACT TRUNCATED AT 250 WORDS) <\/jats:p>","DOI":"10.1152\/jappl.1990.68.4.1534","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T16:25:49Z","timestamp":1513873549000},"page":"1534-1541","source":"Crossref","is-referenced-by-count":40,"title":["Influence of adenosine on cerebral blood flow during hypoxic hypoxia in the newborn piglet"],"prefix":"10.1152","volume":"68","author":[{"given":"N.","family":"Laudignon","sequence":"first","affiliation":[{"name":"Developmental Pharmacology and Perinatal Research Unit, McGill University, Montreal, Quebec, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Farri","sequence":"additional","affiliation":[{"name":"Developmental Pharmacology and Perinatal Research Unit, McGill University, Montreal, Quebec, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Beharry","sequence":"additional","affiliation":[{"name":"Developmental Pharmacology and Perinatal Research Unit, McGill University, Montreal, Quebec, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Rex","sequence":"additional","affiliation":[{"name":"Developmental Pharmacology and Perinatal Research Unit, McGill University, Montreal, Quebec, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. V.","family":"Aranda","sequence":"additional","affiliation":[{"name":"Developmental Pharmacology and Perinatal Research Unit, McGill University, Montreal, Quebec, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1990.68.4.1534","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T15:42:56Z","timestamp":1567957376000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1990.68.4.1534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1990,4,1]]}},"alternative-id":["10.1152\/jappl.1990.68.4.1534"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1990.68.4.1534","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,4,1]]}}}