{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T14:26:26Z","timestamp":1789395986933,"version":"build-2803163510"},"reference-count":0,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1990,12,1]]},"abstract":"<jats:p> The effects of positive end-expiratory pressure (PEEP) on the pulmonary circulation were studied in 14 intact anesthetized dogs with oleic acid (OA) lung injury. Transmural (tm) mean pulmonary arterial pressure (Ppa)\/cardiac index (Q) plots with transmural left atrial pressure (Pla) kept constant were constructed in seven dogs, and Ppa(tm)\/PEEP plots with Q and Pla(tm) kept constant were constructed in seven other dogs. Q was manipulated by using a femoral arteriovenous bypass and a balloon catheter inserted in the inferior vena cava. Pla was manipulated using a balloon catheter placed by thoracotomy in the left atrium. Ppa(tm)\/Q plots were essentially linear. Before OA, the linearly extrapolated pressure intercept of the Ppa(tm)\/Q relationship approximated Pla(tm). OA (0.09 ml\/kg into the right atrium) produced a parallel shift of the Ppa(tm)\/Q relationship to higher pressures; i.e., the extrapolated pressure intercept increased while the slope was not modified. After OA, 4 Torr PEEP (5.4 cmH2O) had no effect on the Ppa(tm)\/Q relationship and 10 Torr PEEP (13.6 cmH2O) produced a slight, not significant, upward shift of this relationship. Changing PEEP from 0 to 12 Torr (16.3 cmH2O) at constant Q before OA led to an almost linear increase of Ppa(tm) from 14 +\/- 1 to 19 +\/- 1 mmHg. After OA, Ppa(tm) increased at 0 Torr PEEP but changing PEEP from 0 to 12 Torr did not significantly affect Ppa(tm), which increased from 19 +\/- 1 to 20 +\/- 1 mmHg. These data suggest that moderate levels of PEEP minimally aggravate the pulmonary hypertension secondary to OA lung injury. <\/jats:p>","DOI":"10.1152\/jappl.1990.69.6.2190","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T18:14:24Z","timestamp":1513880064000},"page":"2190-2196","source":"Crossref","is-referenced-by-count":8,"title":["Effects of PEEP on pulmonary hemodynamics in intact dogs with oleic acid pulmonary edema"],"prefix":"10.1152","volume":"69","author":[{"given":"M.","family":"Leeman","sequence":"first","affiliation":[{"name":"Laboratory of Cardiovascular and Respiratory Physiology, Erasme University Hospital, Brussels, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Lejeune","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular and Respiratory Physiology, Erasme University Hospital, Brussels, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Closset","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular and Respiratory Physiology, Erasme University Hospital, Brussels, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Vachiery","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular and Respiratory Physiology, Erasme University Hospital, Brussels, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Melot","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular and Respiratory Physiology, Erasme University Hospital, Brussels, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Naeije","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular and Respiratory Physiology, Erasme University Hospital, Brussels, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1990.69.6.2190","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T15:50:37Z","timestamp":1567957837000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1990.69.6.2190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1990,12,1]]}},"alternative-id":["10.1152\/jappl.1990.69.6.2190"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1990.69.6.2190","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,12,1]]}}}