{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T18:18:36Z","timestamp":1793729916790,"version":"4.6.1"},"reference-count":0,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1991,1,1]]},"abstract":"<jats:p> Renal function including fluid and electrolyte balance was studied during recovery in eight subjects who developed symptomatic hyponatremia (HN; plasma sodium concentration less than 130 mM) during an 88-km ultramarathon footrace and compared with results for normonatremic runners [NN; n = 18, mean postrace plasma sodium concentration, 138.2 +\/- 1.2 (SE) mM]. Estimated fluid intake during the race for HN was 12.5 +\/- 1.6 (SE) liters over 9 h 41 min (+\/- 28 min). HN excreted a net fluid excess of 2.95 +\/- 0.56 (range 1.2\u20135.9) liters compared with a fluid deficit of 2.7 +\/- 0.3% body weight in NN. The sodium deficit was 153 +\/- 35 mmol in HN and 187 +\/- 37 mmol in NN. Despite the fluid overload, plasma volume was decreased by 24.1 +\/- 5.0% in HN compared with 8.2 +\/- 2.6% in NN. Serum renin activity (5.1 +\/- 2.0 ng.ml-1.h-1), aldosterone concentrations (410 +\/- 34 ng\/l), creatinine clearances (174.8 +\/- 28.2 ml\/min), and urine output (6.4 +\/- 1.0 ml\/min) were markedly elevated in HN during recovery. Thus the hyponatremia of exercise results from fluid retention in subjects who ingest abnormally large fluid volumes during prolonged exercise. <\/jats:p>","DOI":"10.1152\/jappl.1991.70.1.342","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T03:10:31Z","timestamp":1513912231000},"page":"342-348","source":"Crossref","is-referenced-by-count":113,"title":["Evaluation of renal function and fluid homeostasis during recovery from exercise-induced hyponatremia"],"prefix":"10.1152","volume":"70","author":[{"given":"R. A.","family":"Irving","sequence":"first","affiliation":[{"name":"Medical Research Council\/University of Cape Town Bioenergetics of Exercise Research Unit, Department of Physiology, University of Cape Town Medical School, Observatory, South Africa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. D.","family":"Noakes","sequence":"additional","affiliation":[{"name":"Medical Research Council\/University of Cape Town Bioenergetics of Exercise Research Unit, Department of Physiology, University of Cape Town Medical School, Observatory, South Africa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Buck","sequence":"additional","affiliation":[{"name":"Medical Research Council\/University of Cape Town Bioenergetics of Exercise Research Unit, Department of Physiology, University of Cape Town Medical School, Observatory, South Africa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"van Zyl Smit","sequence":"additional","affiliation":[{"name":"Medical Research Council\/University of Cape Town Bioenergetics of Exercise Research Unit, Department of Physiology, University of Cape Town Medical School, Observatory, South Africa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Raine","sequence":"additional","affiliation":[{"name":"Medical Research Council\/University of Cape Town Bioenergetics of Exercise Research Unit, Department of Physiology, University of Cape Town Medical School, Observatory, South Africa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Godlonton","sequence":"additional","affiliation":[{"name":"Medical Research Council\/University of Cape Town Bioenergetics of Exercise Research Unit, Department of Physiology, University of Cape Town Medical School, Observatory, South Africa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. J.","family":"Norman","sequence":"additional","affiliation":[{"name":"Medical Research Council\/University of Cape Town Bioenergetics of Exercise Research Unit, Department of Physiology, University of Cape Town Medical School, Observatory, South Africa."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1991.70.1.342","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T16:52:33Z","timestamp":1567961553000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1991.70.1.342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1991,1,1]]}},"alternative-id":["10.1152\/jappl.1991.70.1.342"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1991.70.1.342","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,1,1]]}}}