{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T17:15:12Z","timestamp":1794071712789,"version":"4.8.0"},"reference-count":0,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1991,6,1]]},"abstract":"<jats:p> To determine whether endotoxemia and release of tumor necrosis factor (TNF-alpha) and\/or interleukin 1 alpha (IL-1 alpha) are involved in the pathogenesis of heatstroke, 17 adult patients with a mean rectal temperature of 42.1 +\/- 0.2 degrees C were studied. Blood samples were taken on admission and after cooling was completed. TNF-alpha and IL-1 alpha levels were measured by enzyme-linked immunosorbent assay, and lipopolysaccharide (LPS) content was measured by the chromogenic substrate modification of the Limulus amebocyte lysate. TNF-alpha, IL-1 alpha, and LPS were elevated in all patients [199 +\/- 25 (SE) pg\/ml, 480.5 +\/- 68.3 pg\/ml, and 8.60 +\/- 1.19 ng\/ml, respectively, compared with normal control values of 31.4 +\/- 8.4 pg\/ml, 53.7 +\/- 5.32 pg\/ml, and less than 9 pg\/ml]. There was no significant correlation between temperature and the circulating concentration of TNF-alpha, IL-1 alpha, and LPS. Postcooling TNF-alpha, IL-1 alpha, and LPS concentrations were significantly decreased but still above normal control values. The findings suggest that these mediators may have a role in the pathogenesis of heatstroke that could change the strategy of management. <\/jats:p>","DOI":"10.1152\/jappl.1991.70.6.2640","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T04:07:22Z","timestamp":1513915642000},"page":"2640-2644","source":"Crossref","is-referenced-by-count":200,"title":["Endotoxemia and release of tumor necrosis factor and interleukin 1 alpha in acute heatstroke"],"prefix":"10.1152","volume":"70","author":[{"given":"A.","family":"Bouchama","sequence":"first","affiliation":[{"name":"Department of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. S.","family":"Parhar","sequence":"additional","affiliation":[{"name":"Department of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"el-Yazigi","sequence":"additional","affiliation":[{"name":"Department of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Sheth","sequence":"additional","affiliation":[{"name":"Department of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"al-Sedairy","sequence":"additional","affiliation":[{"name":"Department of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1991.70.6.2640","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T16:59:30Z","timestamp":1567961970000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1991.70.6.2640"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1991,6,1]]}},"alternative-id":["10.1152\/jappl.1991.70.6.2640"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1991.70.6.2640","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,6,1]]}}}