{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T15:46:02Z","timestamp":1759160762612},"reference-count":0,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1991,8,1]]},"abstract":"<jats:p> To determine whether thyrotoxicosis has an effect on the asthmatic state in subjects with mild asthma, airway responsiveness, lung function, and exercise capacity were measured in a randomized double-blind placebo-controlled trial before and after liothyronine (triiodothyronine, T3)-induced thyrotoxicosis. Baseline evaluation of 15 subjects with mild asthma included clinical evaluation, thyroid and routine pulmonary function tests, airway responsiveness assessment by methacholine inhalation challenge, and a symptom-limited maximal exercise test. For all subjects, the initial testing revealed that the dose of methacholine which provoked a 20% fall in forced expiratory volume in 1s (PD20) was in a range consistent with symptomatic asthma. There was no significant change in pulmonary function tests, airway reactivity (PD20), or exercise capacity in either the placebo or the T3-treated groups. Thyroid function tests confirmed mild sustained thyrotoxicosis in the T3-treated groups. We conclude that mild T3-induced thyrotoxicosis of 4-wk duration had no effect on lung function, airway responsiveness, or exercise capacity in subjects with mild asthma. <\/jats:p>","DOI":"10.1152\/jappl.1991.71.2.438","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T23:04:07Z","timestamp":1513897447000},"page":"438-444","source":"Crossref","is-referenced-by-count":6,"title":["Effect of triiodothyronine-induced thyrotoxicosis on airway hyperresponsiveness"],"prefix":"10.1152","volume":"71","author":[{"given":"H. M.","family":"Hollingsworth","sequence":"first","affiliation":[{"name":"Division of Pulmonary, University of Massachusetts Medical School, Worcester 01655."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. R.","family":"Pratter","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, University of Massachusetts Medical School, Worcester 01655."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Dubois","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, University of Massachusetts Medical School, Worcester 01655."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. E.","family":"Braverman","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, University of Massachusetts Medical School, Worcester 01655."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. S.","family":"Irwin","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, University of Massachusetts Medical School, Worcester 01655."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1991.71.2.438","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T12:58:56Z","timestamp":1567947536000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1991.71.2.438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1991,8,1]]}},"alternative-id":["10.1152\/jappl.1991.71.2.438"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1991.71.2.438","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,8,1]]}}}