{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T19:54:37Z","timestamp":1725047677525},"reference-count":0,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1991,11,1]]},"abstract":"<jats:p> We examined the contribution of afferent vagal A- and C-fibers on abdominal expiratory muscle activity (EMA). In seven spontaneously breathing supine dogs anesthetized with alpha-chloralose we recorded the electromyogram of the external oblique muscle at various vagal temperatures before and after the induction of a pneumothorax. When myelinated fibers were blocked selectively by cooling the vagus nerves to 7 degrees C, EMA decreased to 40% of control (EMA at 39 degrees C). With further cooling to 0 degrees C, removing afferent vagal C-fiber activity, EMA returned to 72% of control. On rewarming the vagus nerves to 39 degrees C, we then induced a pneumothorax (27 ml\/kg) that eliminated the EMA in all the dogs studied. Cooling the vagus nerves to 7 degrees C, during the pneumothorax, produced a slight though not significant increase in EMA. However, further cooling of the vagus nerves to 0 degrees C caused the EMA to return vigorously to 116% of control. In three dogs, intravenous infusion of a constant incrementally increasing dose of capsaicin, a C-fiber stimulant, decreased EMA in proportion to the dose delivered. These results suggest that EMA is modulated by a balance between excitatory vagal A-fiber activity, most likely from slowly adapting pulmonary stretch receptors, and inhibitory C-fiber activity, most likely from lung C-fibers. <\/jats:p>","DOI":"10.1152\/jappl.1991.71.5.1795","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T05:06:45Z","timestamp":1513919205000},"page":"1795-1800","source":"Crossref","is-referenced-by-count":6,"title":["Role of vagal afferents in the control of abdominal expiratory muscle activity in the dog"],"prefix":"10.1152","volume":"71","author":[{"given":"S. B.","family":"Hollstien","sequence":"first","affiliation":[{"name":"Department of Human Physiology, School of Medicine, University of California, Davis 95616."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. L.","family":"Carl","sequence":"additional","affiliation":[{"name":"Department of Human Physiology, School of Medicine, University of California, Davis 95616."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. S.","family":"Schelegle","sequence":"additional","affiliation":[{"name":"Department of Human Physiology, School of Medicine, University of California, Davis 95616."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. F.","family":"Green","sequence":"additional","affiliation":[{"name":"Department of Human Physiology, School of Medicine, University of California, Davis 95616."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1991.71.5.1795","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T17:07:14Z","timestamp":1567962434000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1991.71.5.1795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,11,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1991,11,1]]}},"alternative-id":["10.1152\/jappl.1991.71.5.1795"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1991.71.5.1795","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,11,1]]}}}