{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T16:58:18Z","timestamp":1758473898381},"reference-count":0,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1992,4,1]]},"abstract":"<jats:p> To determine if prophylactic corticosteroids would prevent acute lung injury caused by hyperoxia and barotrauma, 29 piglets (1.2 +\/- 0.3 kg, 1\u20132 days of age) were studied. Ten piglets were hyperventilated [arterial PCO2 (PaCO2) 15\u201320 Torr] with 100% O2 for 48 h and compared with 10 piglets treated with the identical management but given 0.7 mg\/kg of dexamethasone at time 0 and every 12 h for the 48-h study. Six piglets were normally ventilated (PaCO2 40\u201345 Torr) for 48 h with 21% O2 as an additional control group. Pulmonary function and tracheal aspirates were examined at time 0 and every 24 h. Bronchoalveolar lavage was performed for surfactant analyses at the conclusion of the study. In animals treated with hyperoxia and hyperventilation, lung compliance decreased 32% and tracheal aspirate polymorphonuclear leukocyte (PMN) chemotactic activity increased by 51%, cell counts by 204%, number of PMNs by 277%, elastase activity by 111%, and albumin concentration by 328% over 48 h (P less than 0.05). In contrast, dexamethasone-treated piglets had increases in only tracheal aspirate albumin concentration (206%) over the 48-h study. All cellular and biochemical variables were lower in dexamethasone-treated compared with hyperoxic hyperventilated piglets. Room air normal ventilation controls had only a 108% increase in tracheal aspirate albumin concentration noted. Despite quantitative differences in surfactant among the three groups, activity was unaffected. Results indicate that hyperoxia and hyperventilation for 48 h causes significant inflammatory changes and acute lung injury and that prophylactic high-dose dexamethasone significantly ameliorates this lung damage. <\/jats:p>","DOI":"10.1152\/jappl.1992.72.4.1320","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T06:08:12Z","timestamp":1513922892000},"page":"1320-1325","source":"Crossref","is-referenced-by-count":9,"title":["Prophylactic effects of dexamethasone in lung injury caused by hyperoxia and hyperventilation"],"prefix":"10.1152","volume":"72","author":[{"given":"J. M.","family":"Davis","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Neonatology, Hematology-Oncology, University of Rochester School of Medicine and Dentistry, New York 14642."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Whitin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Neonatology, Hematology-Oncology, University of Rochester School of Medicine and Dentistry, New York 14642."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1992.72.4.1320","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T17:12:30Z","timestamp":1567962750000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1992.72.4.1320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1992,4,1]]}},"alternative-id":["10.1152\/jappl.1992.72.4.1320"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1992.72.4.1320","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,4,1]]}}}