{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T04:02:43Z","timestamp":1789358563181,"version":"build-2803163510"},"reference-count":0,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1992,11,1]]},"abstract":"<jats:p> In 11 healthy subjects (8 males and 3 females, age 21\u201359 yr) left ventricular end-diastolic (LVEDV) and end-systolic (LVESV) volumes were measured in the supine position by isotope cardiography at rest and during two submaximal one-legged exercise loads before and 1 h after acute plasma expansion (PE) by use of a 6% dextran solution (500\u2013750 ml). After PE, blood volume increased from 5.22 +\/- 0.92 to 5.71 +\/- 1.02 (SD) liters (P &lt; 0.01). At rest, cardiac output increased 30% (5.3 +\/- 1.0 to 6.9 +\/- 1.6 l\/min; P &lt; 0.01), stroke volume increased from 90 +\/- 20 to 100 +\/- 28 ml (P &lt; 0.05), and LVEDV increased from 134 +\/- 29 to 142 +\/- 40 ml (NS). LVESV was unchanged (44 +\/- 11 and 42 +\/- 14 ml). Heart rate rose from 60 +\/- 7 to 71 +\/- 10 beats\/min (P &lt; 0.01). The cardiac preload [central venous pressure (CVP)] was insignificantly elevated (4.9 +\/- 2.1 and 5.3 +\/- 3.0 mmHg); systemic vascular resistance and arterial pressures were significantly reduced (mean pressure fell from 91 +\/- 11 to 85 +\/- 11 mmHg, P &lt; 0.01). Left ventricular peak filling and peak ejection rates both increased (19 and 14%, respectively; P &lt; 0.05). During exercise, cardiac output remained elevated after PE compared with the control situation, predominantly due to a 10- to 14-ml rise in stroke volume caused by an increased LVEDV, whereas LVESV was unchanged. CVP increased after PE by 2.1 and 3.0 mmHg, respectively (P &lt; 0.05).2+ remained unchanged during exercise compared with rest after PE in <\/jats:p>","DOI":"10.1152\/jappl.1992.73.5.1791","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T23:21:29Z","timestamp":1513898489000},"page":"1791-1796","source":"Crossref","is-referenced-by-count":21,"title":["Acute plasma expansion: left ventricular hemodynamics and endocrine function during exercise"],"prefix":"10.1152","volume":"73","author":[{"given":"I. L.","family":"Kanstrup","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Glostrup Hospital, University of Copenhagen, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Marving","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Glostrup Hospital, University of Copenhagen, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. F.","family":"Hoilund-Carlsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Glostrup Hospital, University of Copenhagen, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1992.73.5.1791","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T16:22:30Z","timestamp":1567959750000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1992.73.5.1791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,11,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1992,11,1]]}},"alternative-id":["10.1152\/jappl.1992.73.5.1791"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1992.73.5.1791","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,11,1]]}}}