{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T03:39:00Z","timestamp":1773459540466,"version":"3.50.1"},"reference-count":0,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1992,12,1]]},"abstract":"<jats:p> It is known that during exercise there is an increase in plasma epinephrine. The purpose of the present investigation was to determine whether stimulation of carotid chemoreceptors by epinephrine is a direct effect or secondary to epinephrine-induced increases in arterial plasma [K+] and whole body CO2 production (VCO2). Chemoreceptor discharge was recorded from single fiber preparations of the carotid sinus nerves in anesthetized cats ventilated to a constant arterial PCO2 (PaCO2). Infusion of epinephrine (1 microgram.kg-1 x min-1) caused arterial [K+] to increase from a mean of 2.7 to 3.8 mM. VCO2 increased so that ventilation had to be increased by 60% to maintain PaCO2 constant. Mean chemoreceptor discharge increased by 50%, but this was no greater than would be predicted on the basis of the increases in arterial [K+] and VCO2. In a further group of experiments epinephrine was infused at 0.1 microgram.kg-1 x min-1 and produced no significant increase in chemoreceptor firing. These experiments provide no evidence for epinephrine having a direct effect on the carotid chemoreceptor. <\/jats:p>","DOI":"10.1152\/jappl.1992.73.6.2420","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T22:59:03Z","timestamp":1513897143000},"page":"2420-2424","source":"Crossref","is-referenced-by-count":6,"title":["Carotid chemoreceptor discharge during epinephrine infusion in anesthetized cats"],"prefix":"10.1152","volume":"73","author":[{"given":"R. A.","family":"Linton","sequence":"first","affiliation":[{"name":"Laboratory of Applied Physiology, Sherrington School of Physiology, St. Thomas's Hospital, London, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. M.","family":"Band","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Physiology, Sherrington School of Physiology, St. Thomas's Hospital, London, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. B.","family":"Wolff","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Physiology, Sherrington School of Physiology, St. Thomas's Hospital, London, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1992.73.6.2420","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T16:19:51Z","timestamp":1567959591000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1992.73.6.2420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1992,12,1]]}},"alternative-id":["10.1152\/jappl.1992.73.6.2420"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1992.73.6.2420","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,12,1]]}}}