{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:49:12Z","timestamp":1787017752814,"version":"build-2736575974"},"reference-count":0,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1992,12,1]]},"abstract":"<jats:p>Stimulation of endogenous opiate secretion worsens circulatory dysfunction in several forms of shock, in part by inhibiting sympathetic activity. To investigate whether endogenous opiates have a similar effect in chronic heart failure (HF), we measured beta-endorphin concentrations and hemodynamic responses to naloxone infusion (2 mg\/kg bolus + 2 mg.kg-1 x h-1) in six control (C) dogs and eight dogs with low-output HF produced by 3 wk of rapid ventricular pacing. The dogs with HF exhibited reduced arterial blood pressure (C, 123 +\/- 4 vs. HF, 85 +\/- 7 mmHg; P &lt; 0.01) and cardiac outputs (C, 179 +\/- 14 vs. HF, 76 +\/- 2 ml.min-1 x kg-1; P &lt; 0.01) and elevated plasma norepinephrine concentrations (C, 99 +\/- 12 vs. HF, 996 +\/- 178 pg\/ml; P &lt; 0.01) but normal beta-endorphin concentrations (C, 30 +\/- 11 vs. HF, 34 +\/- 12 pg\/ml; P = NS). Naloxone produced similar transitory increases in blood pressure (C, 14 +\/- 5 vs. HF, 26 +\/- 25%) and cardiac output (C, 37 +\/- 13 vs. HF, 22 +\/- 15%) in both groups (both P = NS). No significant changes in norepinephrine concentration or systemic vascular resistance were observed in either group. These findings suggest that beta-endorphin secretion does not exacerbate circulatory dysfunction in chronic heart failure.<\/jats:p>","DOI":"10.1152\/jappl.1992.73.6.2675","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T17:59:03Z","timestamp":1513879143000},"page":"2675-2680","source":"Crossref","is-referenced-by-count":2,"title":["Effect of chronic left ventricular failure on beta-endorphin"],"prefix":"10.1152","volume":"73","author":[{"given":"E.","family":"Mellow","sequence":"first","affiliation":[{"name":"Cardiovascular Section, New York Hospital-Cornell Medical Center, New York 10021."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Redei","sequence":"additional","affiliation":[{"name":"Cardiovascular Section, New York Hospital-Cornell Medical Center, New York 10021."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Marzo","sequence":"additional","affiliation":[{"name":"Cardiovascular Section, New York Hospital-Cornell Medical Center, New York 10021."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. R.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Cardiovascular Section, New York Hospital-Cornell Medical Center, New York 10021."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1992.73.6.2675","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T12:20:11Z","timestamp":1567945211000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1992.73.6.2675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1992,12,1]]}},"alternative-id":["10.1152\/jappl.1992.73.6.2675"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1992.73.6.2675","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,12,1]]}}}