{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T20:48:52Z","timestamp":1699994932559},"reference-count":0,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1993,6,1]]},"abstract":"<jats:p> We studied the pleural inflammatory response to tube thoracostomy by inserting an Argyle 32-Fr tube in the pleural space of 10 anesthetized sheep. An experimental pleural effusion was created by infusion of sterile normal saline (10 ml\/kg) into the pleural space, and the animals were allowed to recover. Systemic blood and experimental pleural effusion (EPE) samples were obtained at time 0, 30 min, hourly for 6 h, and at 6-h intervals for a total of 48 h. EPE white cell count rose from 125 +\/- 125 to 6,323 +\/- 2,268\/microliters (SE) at 6 h (P &lt; 0.05) but showed marked variability at 42 and 48 h (P &lt; 0.05), with values ranging from 8,000 to 22,000\/microliters. The systemic white cell count rose from 5,195 +\/- 914 to 9,640 +\/- 1,110\/microliters (P &lt; 0.01) within the first 12 h and then remained stable. EPE protein increased from 0 +\/- 0 to 3.73 +\/- 0.2 g\/dl at 48 h (P &lt; 0.05). EPE lactate dehydrogenase rose from 44 +\/- 12 IU\/l to a peak of 638 +\/- 55 IU\/l at 24 h (P &lt; 0.05). EPE glucose was significantly lower than serum glucose at 36, 42, and 48 h (P &lt; 0.05). These data indicate that chest tube placement rapidly induces significant pleural inflammation and results in formation of a sterile exudate. <\/jats:p>","DOI":"10.1152\/jappl.1993.74.6.2782","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T00:48:51Z","timestamp":1513903731000},"page":"2782-2787","source":"Crossref","is-referenced-by-count":2,"title":["Effects of tube thoracostomy on pleural fluid characteristics in sheep"],"prefix":"10.1152","volume":"74","author":[{"given":"P.","family":"Carvalho","sequence":"first","affiliation":[{"name":"Pulmonary Research Laboratory, Department of Veterans Affairs Medical Center, Boise, Idaho 83702."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Kirk","sequence":"additional","affiliation":[{"name":"Pulmonary Research Laboratory, Department of Veterans Affairs Medical Center, Boise, Idaho 83702."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Butler","sequence":"additional","affiliation":[{"name":"Pulmonary Research Laboratory, Department of Veterans Affairs Medical Center, Boise, Idaho 83702."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. B.","family":"Charan","sequence":"additional","affiliation":[{"name":"Pulmonary Research Laboratory, Department of Veterans Affairs Medical Center, Boise, Idaho 83702."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1993.74.6.2782","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T16:37:36Z","timestamp":1567960656000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1993.74.6.2782"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1993,6,1]]}},"alternative-id":["10.1152\/jappl.1993.74.6.2782"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1993.74.6.2782","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,6,1]]}}}