{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T03:05:10Z","timestamp":1771643110638,"version":"3.50.1"},"reference-count":0,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1993,9,1]]},"abstract":"<jats:p> Dead space (VD) loading has been shown to cause an increase in tidal volume and a decrease in respiratory frequency at moderate to high levels of ventilation (VI) during exercise (J. Appl. Physiol. 70: 55\u201362, 1991). This study examined the role of carotid chemoreceptors (CC) in the breathing pattern response to added VD during maximal incremental exercise; we used hyperoxia to silence the CC. Nine healthy subjects exercised on a bicycle ergometer on 4 different days while inspiring air with VD (AVD) and without VD [air control (AC)] and while inspiring 100% O2 with VD (O2VD) and without VD (O2C). Equipment resistance for VD and control studies was identical, and the exercise tests were done in a randomized order. At a matched level of VI equivalent to 75% VI at the end of the AC experiments (102 l\/min), the breathing pattern in the AVD and O2VD tests was significantly deeper and slower (P &lt; 0.05) than that in the AC and O2C tests. The difference in tidal volume between AVD and AC tests (delta = 0.26 +\/- 0.16 liter) was not significantly different from that between O2VD and O2C tests (delta = 0.23 +\/- 0.23 liter). The breathing pattern was the same in the AC and O2C tests. It is concluded that the altered breathing pattern with VD loading is not mediated by the CC. <\/jats:p>","DOI":"10.1152\/jappl.1993.75.3.1378","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T00:40:08Z","timestamp":1513903208000},"page":"1378-1384","source":"Crossref","is-referenced-by-count":16,"title":["Carotid chemoreceptors and respiratory adaptations to dead space loading during incremental exercise"],"prefix":"10.1152","volume":"75","author":[{"given":"N. C.","family":"Syabbalo","sequence":"first","affiliation":[{"name":"Division of Respiratory Medicine, Royal University Hospital, Saskatoon, Saskatchewan, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Zintel","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Royal University Hospital, Saskatoon, Saskatchewan, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Watts","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Royal University Hospital, Saskatoon, Saskatchewan, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. G.","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Royal University Hospital, Saskatoon, Saskatchewan, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1993.75.3.1378","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T16:33:58Z","timestamp":1567960438000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1993.75.3.1378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1993,9,1]]}},"alternative-id":["10.1152\/jappl.1993.75.3.1378"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1993.75.3.1378","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,9,1]]}}}