{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T20:50:24Z","timestamp":1698353424208},"reference-count":0,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1994,6,1]]},"abstract":"<jats:p> To evaluate the role of pH and temperature in norepinephrine (NE)-mediated decreases in endothelial permeability, we studied bovine pulmonary arterial endothelial monolayers at pH values of 4\u20139 and at temperatures of 35\u201339 degrees C. Only extremes of pH-modulated endothelial permeability and temperature had no effect. Although both NE and 3-isobutyl-1-methylxanthine decreased endothelial permeability, their effects were diminished by low pH and high temperature. Fever and acidosis may contribute to the edema seen in septic shock by a novel mechanism: attenuation of the barrier-improving function of NE. <\/jats:p>","DOI":"10.1152\/jappl.1994.76.6.2760","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T09:31:50Z","timestamp":1513935110000},"page":"2760-2764","source":"Crossref","is-referenced-by-count":6,"title":["pH and temperature modulate norepinephrine-dependent changes in endothelial permeability"],"prefix":"10.1152","volume":"76","author":[{"given":"M. P.","family":"Griffin","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Virginia, Charlottesville 22901."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. R.","family":"Moorman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Virginia, Charlottesville 22901."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1994.76.6.2760","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T17:44:59Z","timestamp":1567964699000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1994.76.6.2760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1994,6,1]]}},"alternative-id":["10.1152\/jappl.1994.76.6.2760"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1994.76.6.2760","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,6,1]]}}}