{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T22:17:46Z","timestamp":1789078666825,"version":"build-2803163510"},"reference-count":0,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1994,8,1]]},"abstract":"<jats:p> We investigated whether hypermagnesemia alleviates hypoxic or group B streptococcal (GBS) pulmonary hypertension (PH). Hypoxic PH was induced and maintained in 14 lambs by continuous ventilation with 12% oxygen. GBS PH was induced and maintained in 16 lambs by the continuous infusion of 5\u201310 x 10(8) colony-forming units.kg-1.h-1 of GBS. After the onset of PH, lambs were randomized to receive either magnesium sulfate (MgSO4, intermittent boluses of 0.38 mmol\/kg, with a continuous infusion of 0.15 mmol.kg-1.h-1) or a similar volume of normal saline. Hypermagnesemia lowered pulmonary arterial pressure (PAP) and delayed the fall in systemic arterial pressure and stroke volume index seen in the control animals (each P &lt; 0.05). At a serum magnesium concentration ([Mg]) of 2.75 +\/- 0.25 mmol\/l, PAP was 27 +\/- 3 compared with 40 +\/- 4 Torr in the control animals ([Mg] = 0.87 +\/- 0.06 mmol\/l; P &lt; 0.05). In the GBS PH trial, hypermagnesemia prevented the continued increase in PAP seen in the control animals. At [Mg] = 2.15 +\/- 0.07 mmol\/l, PAP fell 2 +\/- 1 Torr from prerandomization values, whereas it rose 4 +\/- 2 Torr in the control animals ([Mg] = 0.59 +\/- 0.07 mmol\/l; P &lt; 0.05). However, during the same time the systemic arterial pressure fell further in the magnesium-treated animals (-19 +\/- 1 vs. -2 +\/- 5 Torr). MgSO4 attenuates PH in both models but may cause systemic hypotension in sepsis. <\/jats:p>","DOI":"10.1152\/jappl.1994.77.2.751","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T10:53:36Z","timestamp":1513940016000},"page":"751-756","source":"Crossref","is-referenced-by-count":14,"title":["Magnesium attenuates pulmonary hypertension due to hypoxia and group B streptococci"],"prefix":"10.1152","volume":"77","author":[{"given":"M. E.","family":"Anderson","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Tennessee Medical Center at Knoxville 37920."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. M.","family":"Burnette","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Tennessee Medical Center at Knoxville 37920."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. R.","family":"Geiser","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Tennessee Medical Center at Knoxville 37920."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Janjindamai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Tennessee Medical Center at Knoxville 37920."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1994.77.2.751","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T17:56:41Z","timestamp":1567965401000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1994.77.2.751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1994,8,1]]}},"alternative-id":["10.1152\/jappl.1994.77.2.751"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1994.77.2.751","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,8,1]]}}}