{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:19:21Z","timestamp":1774916361255,"version":"3.50.1"},"reference-count":0,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1994,10,1]]},"abstract":"<jats:p> Efficiency of cough for clearing mucus from the lungs is believed to be a function of peak airflow velocities in the airways. Initial transient supramaximal flows are characteristic of cough, and these peak flow rates can be enhanced by placing a triggered shutter at the mouth, serving the role of the epiglottis. Using radiolabeled monodispersed aerosols (99mTc-iron oxide) and gamma camera analysis, we measured over a 2-h period the efficacy of 60 voluntary vs. shutter coughs for clearing mucus from the airways of patients (n = 15) with chronic airway obstruction (mean ratio of forced expired volume in 1 s to forced vital capacity = 0.55). In a subset of patients (n = 9), we also measured the efficacy of forced expirations, or huffs, without glottis closure. Peak flow rate was greater for shutter than voluntary coughs [9.4 +\/- 2.0 (SD) vs. 4.1 +\/- 1.9 l\/s; P &lt; 0.001]. Retention at 60 min (as a fraction of initial deposition) was significantly different for the 3 study days (control, 0.83 +\/- 0.17; voluntary cough, 0.69 +\/- 0.18; shutter cough, 0.75 +\/- 0.19; P = 0.01), but only control vs. voluntary cough values were significantly different from each other (P = 0.01). In contrast, retention at 120 min was significantly different for the 3 days, but both voluntary and shutter coughs were significantly different from control (P = 0.01 and P = 0.02, respectively) (control, 0.73 +\/- 0.16; voluntary cough, 0.61 +\/- 0.20; shutter cough, 0.65 +\/- 0.20). Patients studied with buffs showed a clearance rate faster than control and similar to that associated with voluntary cough.(ABSTRACT TRUNCATED AT 250 WORDS) <\/jats:p>","DOI":"10.1152\/jappl.1994.77.4.1577","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T10:29:18Z","timestamp":1513938558000},"page":"1577-1583","source":"Crossref","is-referenced-by-count":27,"title":["Effect of enhanced supramaximal flows on cough clearance"],"prefix":"10.1152","volume":"77","author":[{"given":"W. D.","family":"Bennett","sequence":"first","affiliation":[{"name":"Department of Medicine, University of North Carolina at Chapel Hill 27599."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. L.","family":"Zeman","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of North Carolina at Chapel Hill 27599."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1994.77.4.1577","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T17:54:06Z","timestamp":1567965246000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1994.77.4.1577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994,10,1]]}},"alternative-id":["10.1152\/jappl.1994.77.4.1577"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1994.77.4.1577","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,10,1]]}}}