{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T20:02:33Z","timestamp":1772049753101,"version":"3.50.1"},"reference-count":0,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1995,12,1]]},"abstract":"<jats:p> We previously found that up to 15% of the normal cardiac output can flow through lungs that are entirely in zone 1 and that the zone 1 pathway utilizes alveolar corner vessels. Because of the proximity of these vessels to alveoli, we hypothesized that lungs perfused under zone 1 conditions would exchange gas. We used the multiple inert gas elimination technique to assess the ventilation-perfusion (VA\/Q) distribution under zones 1 and 2 in six rabbit lungs perfused with tris(hydroxymethyl)aminomethane-buffered Tyrode solution containing 1% albumin, 4% dextran, and papaverine (25 mg\/l). High-frequency oscillation (tidal volume = 2.8 ml at 20 Hz, bias flow = 1 l\/min) kept alveolar pressure (PA) nearly constant at 10 or 20 cmH2O. Pulmonary arterial pressure was set 2.5 cmH2O below or 5 cmH2O above PA (zones 1 and 2, respectively). Pulmonary venous pressure was kept at 0 cmH2O, with zero reference being the bottom of the lung. At PA of 10 cmH2O, flow was 64 +\/- 40 and 5 +\/- 3 ml\/min (P &lt; 0.05) and the mean VA\/Q for perfusion was 1.1 +\/- 0.4 and &gt; 5 (P &lt; 0.05) in zones 2 and 1, respectively. At PA of 20 cmH2O, flow was 89 +\/- 36 and 22 +\/- 13 ml\/min (P &lt; 0.05) and the mean VA\/Q for perfusion was 0.8 +\/- 0.3 and 3.7 +\/- 2.4 (P &lt; 0.05) in zones 2 and 1, respectively. Shunt averaged &lt; 5% of total flow in all conditions. Blood flowing through vessels remaining open under zone 1 conditions 1) exchanges gas, 2) does not occur through anatomic or physiological shunts, and 3) may explain the high VA\/Q seen with positive end-expiratory pressure. <\/jats:p>","DOI":"10.1152\/jappl.1995.79.6.1895","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T12:04:17Z","timestamp":1513944257000},"page":"1895-1899","source":"Crossref","is-referenced-by-count":10,"title":["Perfusion through vessels open in zone 1 contributes to gas exchange in rabbit lungs in situ"],"prefix":"10.1152","volume":"79","author":[{"given":"W. J.","family":"Lamm","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Washington, Seattle 98104, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Obermiller","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington, Seattle 98104, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. P.","family":"Hlastala","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington, Seattle 98104, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. K.","family":"Albert","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington, Seattle 98104, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1995.79.6.1895","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T18:04:43Z","timestamp":1567965883000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1995.79.6.1895"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1995,12,1]]}},"alternative-id":["10.1152\/jappl.1995.79.6.1895"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1995.79.6.1895","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,12,1]]}}}