{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T19:34:52Z","timestamp":1675798492915},"reference-count":0,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1996,1,1]]},"abstract":"<jats:p> To gain insight into the role of cerebral lactic acidosis in the hypoxic ventilatory response, we administered dichloroacetate (DCA) intravenously to inhibit lactic acid production in 7 awake goats (40-70 kg) during 0.5 h of normoxia (inspired O2 fraction = 0.209) and 5 h of poikilocapnic hypoxia (inspired O2 fraction = 0.125). On separate days, these goats were also studied with a continuous saline infusion (18 ml\/h iv) during 5 h of normoxia and hypoxia. Arterial PCO2 (PaCO2) did not change during the 5-h normoxic period. During hypoxia, arterial PO2 fell significantly (P &lt; 0.05) with both saline (from 111.3 to 39.0 Torr) and DCA (from 111.8 to 42.0 Torr) infusions. PaCO2 decreased (P &lt; 0.05) during the first 0.5 h of both the saline and DCA hypoxia protocols. The decrease was greater (P &lt; 0.05) during DCA (from 36.5 to 33.5 Torr) than during saline infusion (from 37.7 to 36.3 Torr). With saline infusion, PaCO2 decreased (P &lt; 0.05) by 4.9 Torr between 0.5 and 5.0 h of hypoxia. However, over this period of DCA hypoxia, PaCO2 did not significantly decrease (P = 0.05). We conclude that the enhanced hyperventilation with DCA during acute hypoxia is consistent with brain lactic acidosis depressing breathing. Absence of additional significant hyperventilation after 0.5 h of DCA hypoxia suggests that a time-dependent alleviation of brain lactic acidosis might normally contribute to ventilatory acclimatization to hypoxia. <\/jats:p>","DOI":"10.1152\/jappl.1996.80.1.176","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T01:48:56Z","timestamp":1513907336000},"page":"176-181","source":"Crossref","is-referenced-by-count":5,"title":["Effect of dichloroacetate on PaCO2 responses to hypoxia in awake goats"],"prefix":"10.1152","volume":"80","author":[{"given":"E. A.","family":"Aaron","sequence":"first","affiliation":[{"name":"Department of Physiology, Medical College of Wisconsin, Milwaukee 53226, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. V.","family":"Forster","sequence":"additional","affiliation":[{"name":"Department of Physiology, Medical College of Wisconsin, Milwaukee 53226, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. F.","family":"Lowry","sequence":"additional","affiliation":[{"name":"Department of Physiology, Medical College of Wisconsin, Milwaukee 53226, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Korducki","sequence":"additional","affiliation":[{"name":"Department of Physiology, Medical College of Wisconsin, Milwaukee 53226, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. J.","family":"Ohtake","sequence":"additional","affiliation":[{"name":"Department of Physiology, Medical College of Wisconsin, Milwaukee 53226, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1996.80.1.176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T13:19:55Z","timestamp":1567948795000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1996.80.1.176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1996,1,1]]}},"alternative-id":["10.1152\/jappl.1996.80.1.176"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1996.80.1.176","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,1,1]]}}}