{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:08:23Z","timestamp":1789783703961,"version":"4.0.1"},"reference-count":0,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1996,6,1]]},"abstract":"<jats:p> Central apneas have been reported to occur in the rat during all stages of sleep. Two types of apnea have been described: spontaneous and postsigh, which are immediately preceded by an augmented breath. We studied the effect of inspired gas on the number and type of apneas in nine adult male Sprague-Dawley rats that were surgically prepared with cortical electroencephalogram and nuchal electromyogram electrodes. In addition to the electroencephalogram and electromyogram, we recorded respiration by the barometric method by using a single-chamber plethysmograph. Each rat was recorded from 1000 until 1600 on 4 separate days by using different inspired gases: room air, 100% O2, 15% O2, and 5% CO2. We found that the sleep-related apnea index was significantly higher during 100% O2 compared with room air (P &lt; 0.05) and was significantly lower during 15% O2 and 5% CO2 compared with room air (P &lt; 0.05). Postsigh apneas occurred more frequently than did spontaneous apneas (P &lt; 0.0001). The coupling between sighs and apneas was strengthened by hyperoxia and weakened by hypoxia and hypercapnia (P &lt; 0.05 for each). We conclude that stimulation of chemoreceptors acts to oppose apnea in the rat. <\/jats:p>","DOI":"10.1152\/jappl.1996.80.6.2102","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T22:40:28Z","timestamp":1514155228000},"page":"2102-2107","source":"Crossref","is-referenced-by-count":32,"title":["Effects of inspired gas on sleep-related apnea in the rat"],"prefix":"10.1152","volume":"80","author":[{"given":"J.","family":"Christon","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Illinois, Chicago 60612, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. W.","family":"Carley","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Illinois, Chicago 60612, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Monti","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Illinois, Chicago 60612, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Radulovacki","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Illinois, Chicago 60612, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1996.80.6.2102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T03:00:24Z","timestamp":1567998024000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1996.80.6.2102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1996,6,1]]}},"alternative-id":["10.1152\/jappl.1996.80.6.2102"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1996.80.6.2102","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,6,1]]}}}