{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T07:19:36Z","timestamp":1770448776276,"version":"3.49.0"},"reference-count":22,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1996,10,1]]},"abstract":"<jats:p>Hinchcliff, K. W., K. H. McKeever, W. W. Muir, and R. A. Sams. Furosemide reduces accumulated oxygen deficit in horses during brief intense exertion. J. Appl. Physiol. 81(4): 1550\u20131554, 1996.\u2014We theorized that furosemide-induced weight reduction would reduce the contribution of anaerobic metabolism to energy expenditure of horses during intense exertion. The effects of furosemide on accumulated O<jats:sub>2<\/jats:sub>deficit and plasma lactate concentration of horses during high-intensity exercise were examined in a three-way balance randomized crossover study. Nine horses completed each of three trials: 1) a control (C) trial, 2) a furosemide-unloaded (FU) trial in which the horse received furosemide 4 h before running, and 3) a furosemide weight-loaded (FL) trial during which the horse received furosemide and carried weight equal to the weight lost after furosemide administration. Horses ran for 2 min at \u223c120% maximal O<jats:sub>2<\/jats:sub>consumption. Furosemide (FU) increased O<jats:sub>2<\/jats:sub>consumption (ml \u22c5 2 min<jats:sup>\u22121<\/jats:sup>\u22c5 kg<jats:sup>\u22121<\/jats:sup>) compared with C (268 \u00b1 9 and 257 \u00b1 9, P &lt; 0.05), whereas FL was not different from C (252 \u00b1 8). Accumulated O<jats:sub>2<\/jats:sub>deficit (ml O<jats:sub>2<\/jats:sub>equivalents\/kg) was significantly ( P &lt; 0.05) lower during FU (81.2 \u00b1 12.5), but not during FL (96.9 \u00b1 12.4), than during C (91.4 \u00b1 11.5). Rate of increase in blood lactate concentration (mmol \u22c5 2 min<jats:sup>\u22121<\/jats:sup>\u22c5 kg<jats:sup>\u22121<\/jats:sup>) after FU (0.058 \u00b1 0.001), but not after FL (0.061 \u00b1 0.001), was significantly ( P &lt; 0.05) lower than after C (0.061 \u00b1 0.001). Furosemide decreased the accumulated O<jats:sub>2<\/jats:sub>deficit and rate of increase in blood lactate concentration of horses during brief high-intensity exertion. The reduction in accumulated O<jats:sub>2<\/jats:sub>deficit in FU-treated horses was attributable to an increase in the mass-specific rate of O<jats:sub>2<\/jats:sub>consumption during the high-intensity exercise test.<\/jats:p>","DOI":"10.1152\/jappl.1996.81.4.1550","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T07:23:31Z","timestamp":1513927411000},"page":"1550-1554","source":"Crossref","is-referenced-by-count":29,"title":["Furosemide reduces accumulated oxygen deficit in horses during brief intense exertion"],"prefix":"10.1152","volume":"81","author":[{"given":"K. W.","family":"Hinchcliff","sequence":"first","affiliation":[{"name":"Exercise Physiology Laboratory, Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio 43210-1089"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. H.","family":"McKeever","sequence":"additional","affiliation":[{"name":"Exercise Physiology Laboratory, Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio 43210-1089"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. W.","family":"Muir","sequence":"additional","affiliation":[{"name":"Exercise Physiology Laboratory, Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio 43210-1089"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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