{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T05:51:24Z","timestamp":1713592284431},"reference-count":13,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1996,11,1]]},"abstract":" Amis, T. C., N. O\u2019Neill, T. Van der Touw, A. Tully, and A. Brancatisano. Supraglottic airway pressure-flow relationships during oronasal airflow partitioning in dogs. J. Appl. Physiol. 81(5): 1958\u20131964, 1996.\u2014We studied pressure-flow relationships in the supraglottic airway of eight prone mouth-open anesthetized (intravenous chloralose or pentobarbital sodium) crossbred dogs (weight 15\u201326 kg) during increasing respiratory drive (CO2<\/jats:sub>administration; n = 4) and during graded-voltage electrical stimulation (SV; n = 4) of the soft palate muscles. During increased respiratory drive, inspiratory airflow occurred via both the nose (V\u02d9n) and mouth (V\u02d9m), with the ratio of V\u02d9n toV\u02d9m [%(V\u02d9n\/V\u02d9m)] decreasing maximally from 16.0 \u00b1 7.0 (SD) to 2.4 \u00b1 1.6% ( P < 0.05). Simultaneously, oral airway resistance at peak inspiratory flow decreased from 2.1 \u00b1 1.0 to 0.4 \u00b1 0.4 cmH2<\/jats:sub>O ( P < 0.05), whereas nasal airway resistance did not change (14.4 \u00b1 7.2 to 13.1 \u00b1 5.4 cmH2<\/jats:sub>O; P = 0.29). Inspiratory pressure-flow plots of the oral airway were inversely curvilinear or more complex in nature. Nasal pathway plots, however, demonstrated a positive linear relationship in all animals ( r = 0.87 \u00b1 0.11; all P < 0.001). During electrical stimulation of soft palate muscle contraction accompanied by graded constant-inspiratory airflows of 45\u2013385 ml\/s through an isolated upper airway, %(V\u02d9n\/V\u02d9m) decreased from 69 \u00b1 50 to 10 \u00b1 13% at a SV of 84 \u00b1 3% of maximal SV ( P < 0.001). At a SV of 85 \u00b1 1% of maximum, normalized oral airway resistance (expressed as percent baseline) fell to 5 \u00b1 3%, whereas normalized nasal resistance was 80 \u00b1 9% (both P< 0.03). Thus control of oronasal airflow partitioning in dogs appears mediated more by alterations in oral route geometry than by closure of the nasopharyngeal airway. <\/jats:p>","DOI":"10.1152\/jappl.1996.81.5.1958","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T07:12:53Z","timestamp":1513926773000},"page":"1958-1964","source":"Crossref","is-referenced-by-count":2,"title":["Supraglottic airway pressure-flow relationships during oronasal airflow partitioning in dogs"],"prefix":"10.1152","volume":"81","author":[{"given":"T. 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