{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T13:54:42Z","timestamp":1773755682357,"version":"3.50.1"},"reference-count":32,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1996,12,1]]},"abstract":"<jats:p> Nagase, Takahide, Hirotoshi Matsui, Tomoko Aoki, Yasuyoshi Ouchi, and Yoshinosuke Fukuchi. Lung tissue behavior in the mouse during constriction induced by methacholine and endothelin-1. J. Appl. Physiol. 81(6): 2373\u20132378, 1996.\u2014Recently, mice have been extensively used to investigate the pathogenesis of pulmonary disease because appropriate murine models, including transgenic mice, are being increasingly developed. However, little information about the lung mechanics of mice is currently available. We questioned whether lung tissue behavior and the coupling between dissipative and elastic processes, hysteresivity (\u03b7), in mice would be different from those in the other species. To address this question, we investigated whether tissue resistance (Rti) and \u03b7 in mice would be affected by varying lung volume, constriction induced by methacholine (MCh) and endothelin-1 (ET-1), and high-lung-volume challenge during induced constriction. From measured tracheal flow and tracheal and alveolar pressures in open-chest ICR mice during mechanical ventilation [tidal volume = 8 ml\/kg, frequency (f) = 2.5 Hz], we calculated lung resistance (Rl), Rti, airway resistance (Raw), lung elastance (El), and \u03b7 (= 2\u03c0fRti\/El). Under baseline conditions, increasing levels of end-expiratory transpulmonary pressure decreased Raw and increased Rti. The administration of aerosolized MCh and intravenous ET-1 increased Rl, Rti, Raw, and El in a dose-dependent manner. Rti increased from 0.207 \u00b1 0.010 to 0.570 \u00b1 0.058 cmH<jats:sub>2<\/jats:sub>O \u22c5 ml<jats:sup>\u22121<\/jats:sup> \u22c5 s after 10<jats:sup>\u22127<\/jats:sup> mol\/kg ET-1 ( P &lt; 0.01). After induced constriction, increasing end-expiratory transpulmonary pressure decreased Raw. However, \u03b7 was not affected by changing lung volume, constriction induced by MCh and ET-1, or high-lung-volume challenge during induced constriction. These observations suggest that 1) \u03b7 is stable in mice regardless of various conditions, 2) Rti is an important fraction of Rl and increases after induced constriction, and 3) mechanical interdependence may affect airway smooth muscle shortening in this species. In mammalian species, including mice, analysis of \u03b7 may indicate that both Rti and El essentially respond to a similar degree. <\/jats:p>","DOI":"10.1152\/jappl.1996.81.6.2373","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T08:54:00Z","timestamp":1513932840000},"page":"2373-2378","source":"Crossref","is-referenced-by-count":28,"title":["Lung tissue behavior in the mouse during constriction  induced by methacholine and endothelin-1"],"prefix":"10.1152","volume":"81","author":[{"given":"Takahide","family":"Nagase","sequence":"first","affiliation":[{"name":"Department of Geriatrics, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotoshi","family":"Matsui","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyoshi","family":"Ouchi","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinosuke","family":"Fukuchi","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1987.62.5.1878"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1989.66.2.606"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1966.21.1.217"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1987.62.3.1324"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1984.57.3.788"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1989.67.6.2408"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1988.65.6.2490"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(95)00068-2"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1993.75.6.2541"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.60.2.375"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1995.79.2.461"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1987.62.2.807"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1992.72.4.1332"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1989.67.3.1220"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.153.1.8542167"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1961.41.2.281"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1970.28.5.596"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1992.72.1.158"},{"key":"B19","first-page":"1171","volume":"133","author":"Moreno R. 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