{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:51:35Z","timestamp":1791226295055,"version":"4.1.0"},"reference-count":32,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1997,2,1]]},"abstract":"<jats:p>Straus, Christian, Marc Zelter, Jean-Philippe Derenne, Bernard Pidoux, Jean-Claude Willer, and Thomas Similowski.Putative projection of phrenic afferents to the limbic cortex in humans studied with cerebral-evoked potentials. J. Appl. Physiol. 82(2): 480\u2013490, 1997.\u2014Respiratory sensations may rely in part on cortical integration of respiratory afferent information. In an attempt to study such projections, we recorded evoked potentials at scalp and cervical sites in 10 normal volunteers undergoing transcutaneous phrenic stimulation (0.1-ms square pulses, intensity liminal for diaphragmatic activation, series of 600 shocks at 2 Hz). A negative cerebral component of peak latency (12.79 \u00b1 0.54 ms; N13) was constant, and a negative spinal component (7.09 \u00b1 1.04 ms; N7) could also be recorded, all results being reproducible over time. Monitoring of cardiac frequency, skin anesthesia, and stimulation adjacent to the phrenic nerve made the phrenic origin of N7 and N13 the foremost hypothesis. Increasing stimulation frequency and comparison with median nerve stimulation provided arguments for the neural nature of the signals and their cerebral origin. Recordings from intracerebral electrodes in a patient showed a polarity reversal of the evoked potentials at the level of the cingulate gyrus. In conclusion, phrenic stimulation could allow one to study projections of phrenic afferents to the central nervous system in humans. Their exact site and physiological meaning remain to be clarified.<\/jats:p>","DOI":"10.1152\/jappl.1997.82.2.480","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T07:53:49Z","timestamp":1513929229000},"page":"480-490","source":"Crossref","is-referenced-by-count":33,"title":["Putative projection of phrenic afferents to the limbic cortex in humans studied with cerebral-evoked potentials"],"prefix":"10.1152","volume":"82","author":[{"given":"Christian","family":"Straus","sequence":"first","affiliation":[{"name":"Laboratoire de Physiopathologie Respiratoire du Service de Pneumologie,"},{"name":"Service Central d\u2019Explorations Fonctionnelles Respiratoires, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Zelter","sequence":"additional","affiliation":[{"name":"Service Central d\u2019Explorations Fonctionnelles Respiratoires, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Derenne","sequence":"additional","affiliation":[{"name":"Laboratoire de Physiopathologie Respiratoire du Service de Pneumologie,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Pidoux","sequence":"additional","affiliation":[{"name":"Service d\u2019Explorations Fonctionnelles du Syst\u00e8me Nerveux, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, 75651 Paris c\u00e9dex 13, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Claude","family":"Willer","sequence":"additional","affiliation":[{"name":"Service d\u2019Explorations Fonctionnelles du Syst\u00e8me Nerveux, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, 75651 Paris c\u00e9dex 13, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Similowski","sequence":"additional","affiliation":[{"name":"Laboratoire de Physiopathologie Respiratoire du Service de Pneumologie,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1994.00540140036012"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(92)90082-8"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(84)90003-3"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1994.71.5.1646"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1991.sp018824"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1995.sp020947"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1986.60.6.1843"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)91334-4"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(80)90006-1"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(81)91430-9"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(81)90055-9"},{"key":"B13","first-page":"50","volume":"6","author":"Foerster O.","year":"1936","journal-title":"Handbuch der Neurologie"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1991.70.2.491"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(89)90007-8"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1987.sp016445"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1994.76.5.2076"},{"key":"B20","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0272-5231(21)00502-5","volume":"9","author":"Killian K.","year":"1988","journal-title":"Clin. 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