{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:32:58Z","timestamp":1789756378367,"version":"4.0.1"},"reference-count":21,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1997,2,1]]},"abstract":"<jats:p>Canet, Emmanuel, Jean-Paul Praud, and Michel A. Bureau.Periodic breathing induced on demand in awake newborn lamb. J. Appl. Physiol. 82(2): 607\u2013612, 1997.\u2014Spontaneous periodic breathing, although a common feature in fullterm and preterm human infants, is scarce in other newborn mammals. The aim of this study was to induce periodic breathing in lambs. Four 10-day-old and two &lt;48-h-old awake lambs were instrumented with jugular catheters connected to an extracorporeal membrane lung aimed at controlling arterial [Formula: see text]([Formula: see text]). Arterial[Formula: see text]([Formula: see text]) was set and maintained at the desired level by changing inspired O<jats:sub>2<\/jats:sub>fraction and providing O<jats:sub>2<\/jats:sub>through a small catheter into the \u201capneic\u201d lung. At a critical[Formula: see text]\/[Formula: see text]combination, the four 10-day-old lambs exhibited periodic breathing that could be initiated, terminated, and reinitiated on demand. In the 2-day-old lambs with low chemoreceptor gain, periodic breathing was hardly seen, regardless of the trials done to find the critical[Formula: see text]\/[Formula: see text]combination. We conclude that periodic breathing can be induced in lambs and depends on critical[Formula: see text]\/[Formula: see text]combinations and maturity of the chemoreceptors.<\/jats:p>","DOI":"10.1152\/jappl.1997.82.2.607","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T07:53:49Z","timestamp":1513929229000},"page":"607-612","source":"Crossref","is-referenced-by-count":12,"title":["Periodic breathing induced on demand in awake newborn lamb"],"prefix":"10.1152","volume":"82","author":[{"given":"Emmanuel","family":"Canet","sequence":"first","affiliation":[{"name":"Unit\u00e9 de Recherche Pulmonaire, D\u00e9partement de P\u00e9diatrie, Universit\u00e9 de Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Praud","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche Pulmonaire, D\u00e9partement de P\u00e9diatrie, Universit\u00e9 de Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel A.","family":"Bureau","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche Pulmonaire, D\u00e9partement de P\u00e9diatrie, Universit\u00e9 de Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199002000-00003"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1983.sp014906"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1984.sp015229"},{"key":"B4","first-page":"445A","volume":"21","author":"Bureau M. A.","year":"1987","journal-title":"Pediatr. Res."},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1982.52.2.428"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1989.67.3.1226"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1993.74.6.3013"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1966.21.6.1847"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(88)90024-2"},{"key":"B10","first-page":"1163","volume":"133","author":"Dempsey J. A.","year":"1986","journal-title":"Am. Rev. Respir. Dis."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1984.sp015049"},{"key":"B13","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1542\/peds.60.4.418","volume":"60","author":"Hoppenbrouwers T.","year":"1977","journal-title":"Pediatrics"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1982.53.3.644"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197702000-00012"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(83)90086-5"},{"key":"B17","first-page":"57","volume":"9","author":"Milerad J.","year":"1987","journal-title":"J. Dev. Physiol."},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1979.47.3.527"},{"key":"B19","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1542\/peds.50.2.219","volume":"50","author":"Rigatto H.","year":"1972","journal-title":"Pediatrics"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1986.61.1.280"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198104000-00016"},{"key":"B22","first-page":"265","volume":"10","author":"Younes M.","year":"1989","journal-title":"Current Pulmonology"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1997.82.2.607","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T01:35:04Z","timestamp":1660181704000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1997.82.2.607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,2,1]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1997,2,1]]}},"alternative-id":["10.1152\/jappl.1997.82.2.607"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1997.82.2.607","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,2,1]]}}}