{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T02:19:32Z","timestamp":1770344372045,"version":"3.49.0"},"reference-count":27,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1997,2,1]]},"abstract":"<jats:p>Charan, Nirmal B., Shane R. Johnson, S. Lakshminarayan, William H. Thompson, and Paula Carvalho. Nitric oxide and \u03b2-adrenergic agonist-induced bronchial arterial vasodilation. J. Appl. Physiol. 82(2): 686\u2013692, 1997.\u2014In anesthetized sheep, we measured bronchial blood flow (Q\u02d9br) by an ultrasonic flow probe to investigate the interaction between inhaled nitric oxide (NO; 100 parts\/million) given for 5 min and 5 ml of aerosolized isoetharine (1.49 \u00d7 10<jats:sup>\u22122<\/jats:sup>M concentration). NO and isoetharine increased Q\u02d9br from 26.5 \u00b1 6.5 to 39.1 (SE) \u00b1 10.6 and 39.7 \u00b1 10.7 ml\/min, respectively ( n = 5). Administration of NO immediately after isoetharine further increasedQ\u02d9br to 57.3 \u00b1 15.1 ml\/min. NO synthase inhibitor N<jats:sup>\u03c9<\/jats:sup>-nitro-l-arginine methyl ester hydrochloride (l-NAME; 30 mg\/kg, in 20 ml saline given iv) decreased Q\u02d9br to 14.6 \u00b1 2.6 ml\/min. NO given three times alternately with isoetharine progressively increased Q\u02d9br from 14.6 \u00b1 2.6 to 74.3 \u00b1 17.0 ml\/min, suggesting that NO and isoetharine potentiate vasodilator effects of each other. In three other sheep, afterl-NAME, three sequential doses of isoetharine increased Q\u02d9br from 10.2 \u00b1 3.4 to 11.5 \u00b1 5.7, 11.7 \u00b1 4.7, and 13.3 \u00b1 5.7 ml\/min, respectively, indicating that effects of isoetharine are predominantly mediated through synthesis of NO. When this was followed by three sequential administrations of NO, Q\u02d9br increased by 146, 172, and 185%, respectively. Thus in the bronchial circulation there seems to be a close interaction between adenosine 3\u2032,5\u2032-cyclic monophosphate- and guanosine 3\u2032,5\u2032-cyclic monophosphate-mediated vasodilatation.<\/jats:p>","DOI":"10.1152\/jappl.1997.82.2.686","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T07:53:49Z","timestamp":1513929229000},"page":"686-692","source":"Crossref","is-referenced-by-count":17,"title":["Nitric oxide and \u03b2-adrenergic agonist-induced bronchial arterial vasodilation"],"prefix":"10.1152","volume":"82","author":[{"given":"Nirmal B.","family":"Charan","sequence":"first","affiliation":[{"name":"Pulmonary Research Laboratory, Veterans Affairs Medical Center, Boise, Idaho 83702;"},{"name":"Division of Pulmonary\/Critical Care Medicine, Department of Medicine, University of Washington, Seattle, Washington 98195"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shane R.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Pulmonary Research Laboratory, Veterans Affairs Medical Center, Boise, Idaho 83702;"},{"name":"Division of Pulmonary\/Critical Care Medicine, Department of Medicine, University of Washington, Seattle, Washington 98195"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Lakshminarayan","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center, Seattle, Washington 98108; and"},{"name":"Division of Pulmonary\/Critical Care Medicine, Department of Medicine, University of Washington, Seattle, Washington 98195"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William H.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Pulmonary Research Laboratory, Veterans Affairs Medical Center, Boise, Idaho 83702;"},{"name":"Division of Pulmonary\/Critical Care Medicine, Department of Medicine, University of Washington, Seattle, Washington 98195"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Pulmonary Research Laboratory, Veterans Affairs Medical Center, Boise, Idaho 83702;"},{"name":"Division of Pulmonary\/Critical Care Medicine, Department of Medicine, University of Washington, Seattle, Washington 98195"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1993.tb13874.x"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1992.tb09439.x"},{"key":"B3","first-page":"535","volume":"57","author":"Charan N. 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