{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:26:26Z","timestamp":1790666786843,"version":"4.1.0"},"reference-count":29,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1997,7,1]]},"abstract":"<jats:p>Gautier, Henry, Cristina Murariu, and Monique Bonora.Ventilatory and metabolic responses to ambient hypoxia or hypercapnia in rats exposed to CO hypoxia. J. Appl. Physiol.83(1): 253\u2013261, 1997.\u2014We have investigated at ambient temperatures (T<jats:sub>am<\/jats:sub>) of 25 and 5\u00b0C the effects of ambient hypoxia (Hx<jats:sub>am<\/jats:sub>; fractional inspired O<jats:sub>2<\/jats:sub>= 0.14) and hypercapnia (fractional inspired CO<jats:sub>2<\/jats:sub>= 0.04) on ventilation (V\u02d9), O<jats:sub>2<\/jats:sub>uptake (V\u02d9o<jats:sub>2<\/jats:sub>), and colonic temperature (T<jats:sub>c<\/jats:sub>) in 12 conscious rats before and after carotid body denervation (CBD). The rats were concomitantly exposed to CO hypoxia (Hx<jats:sub>CO<\/jats:sub>; fractional inspired CO = 0.03\u20130.05%), which decreases arterial O<jats:sub>2<\/jats:sub>saturation by \u223c25\u201340%. The results demonstrate the following. 1) At T<jats:sub>am<\/jats:sub>of 5\u00b0C, in both intact and CBD rats,V\u02d9\/V\u02d9o<jats:sub>2<\/jats:sub>is larger when Hx<jats:sub>am<\/jats:sub>or CO<jats:sub>2<\/jats:sub>is associated with Hx<jats:sub>CO<\/jats:sub>than with normoxia. At T<jats:sub>am<\/jats:sub>of 25\u00b0C, this is also the case except for CO<jats:sub>2<\/jats:sub>in CBD rats. 2) At T<jats:sub>am<\/jats:sub>of 5\u00b0C, the changes inV\u02d9o<jats:sub>2<\/jats:sub>and T<jats:sub>c<\/jats:sub>seem to result from additive effects of the separate changes induced by Hx<jats:sub>am<\/jats:sub>, CO<jats:sub>2<\/jats:sub>, and Hx<jats:sub>CO<\/jats:sub>. It is concluded that, in conscious rats, central hypoxia does not depress respiratory activity. On the contrary, particularly whenV\u02d9o<jats:sub>2<\/jats:sub>is augmented during a cold stress, bothV\u02d9\/V\u02d9o<jats:sub>2<\/jats:sub>during Hx<jats:sub>CO<\/jats:sub>and the ventilatory responses to Hx<jats:sub>am<\/jats:sub>and CO<jats:sub>2<\/jats:sub>are increased. The mechanisms involved in this relative hyperventilation are likely to involve diencephalic integrative structures.<\/jats:p>","DOI":"10.1152\/jappl.1997.83.1.253","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T08:38:02Z","timestamp":1513931882000},"page":"253-261","source":"Crossref","is-referenced-by-count":15,"title":["Ventilatory and metabolic responses to ambient hypoxia or hypercapnia in rats exposed to CO hypoxia"],"prefix":"10.1152","volume":"83","author":[{"given":"Henry","family":"Gautier","sequence":"first","affiliation":[{"name":"Atelier de Physiologie Respiratoire, Facult\u00e9 de M\u00e9decine Saint-Antoine, 75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Murariu","sequence":"additional","affiliation":[{"name":"Atelier de Physiologie Respiratoire, Facult\u00e9 de M\u00e9decine Saint-Antoine, 75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Bonora","sequence":"additional","affiliation":[{"name":"Atelier de Physiologie Respiratoire, Facult\u00e9 de M\u00e9decine Saint-Antoine, 75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(70)90056-3"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1991.71.4.1254"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/BF00227106"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1995.78.3.856"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1988.sp016922"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(94)90127-9"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.81.2.521"},{"key":"B12","first-page":"565","volume":"18","author":"Gautier H.","year":"1982","journal-title":"Bull. 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