{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T14:41:01Z","timestamp":1773758461211,"version":"3.50.1"},"reference-count":36,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1997,7,1]]},"abstract":"<jats:p> Krishnan, Bharath S., Ron E. Clemens, Trevor A. Zintel, Martin J. Stockwell, and Charles G. Gallagher. Ventilatory response to helium-oxygen breathing during exercise: effect of airway anesthesia. J. Appl. Physiol. 83(1): 82\u201388, 1997.\u2014The substitution of a normoxic helium mixture (HeO<jats:sub>2<\/jats:sub>) for room air (Air) during exercise results in a sustained hyperventilation, which is present even in the first breath. We hypothesized that this response is dependent on intact airway afferents; if so, airway anesthesia (Anesthesia) should affect this response. Anesthesia was administered to the upper airways by topical application and to lower central airways by aerosol inhalation and was confirmed to be effective for over 15 min. Subjects performed constant work-rate exercise (CWE) at 69 \u00b1 2 (SE) % maximal work rate on a cycle ergometer on three separate days: twice after saline inhalation ( days 1 and 3) and once after Anesthesia ( day 2). CWE commenced after a brief warm-up, with subjects breathing Air for the first 5 min (Air-1), HeO<jats:sub>2<\/jats:sub> for the next 3 min, and Air again until the end of CWE (Air-2). The resistance of the breathing circuit was matched for Air and HeO<jats:sub>2<\/jats:sub>. Breathing HeO<jats:sub>2<\/jats:sub> resulted in a small but significant increase in minute ventilation (V\u02d9i) and decrease in alveolar [Formula: see text] in both the Saline (average of 2 saline tests; not significant) and Anesthesia tests. Although Anesthesia had no effect on the sustained hyperventilatory response to HeO<jats:sub>2<\/jats:sub>breathing, theV\u02d9i transients within the first six breaths of HeO<jats:sub>2<\/jats:sub> were significantly attenuated with Anesthesia. We conclude that theV\u02d9i response to HeO<jats:sub>2<\/jats:sub> is not simply due to a reduction in external tubing resistance and that, in humans, airway afferents mediate the transient but not the sustained hyperventilatory response to HeO<jats:sub>2<\/jats:sub> breathing during exercise. <\/jats:p>","DOI":"10.1152\/jappl.1997.83.1.82","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T03:38:02Z","timestamp":1513913882000},"page":"82-88","source":"Crossref","is-referenced-by-count":7,"title":["Ventilatory response to helium-oxygen breathing during exercise: effect of airway anesthesia"],"prefix":"10.1152","volume":"83","author":[{"given":"Bharath S.","family":"Krishnan","sequence":"first","affiliation":[{"name":"Division of Respiratory Medicine, Department of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 0W8"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron E.","family":"Clemens","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 0W8"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trevor A.","family":"Zintel","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 0W8"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin J.","family":"Stockwell","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 0W8"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles G.","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 0W8"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","first-page":"1325","volume":"120","author":"Brain J. 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