{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T09:36:58Z","timestamp":1774345018329,"version":"3.50.1"},"reference-count":22,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1997,9,1]]},"abstract":"<jats:p> N\u00f3brega, Antonio C. L., Jon W. Williamson, Jorge A. Garcia, and Jere H. Mitchell. Mechanisms for increasing stroke volume during static exercise with fixed heart rate in humans. J. Appl. Physiol. 83(3): 712\u2013717, 1997.\u2014Ten patients with preserved inotropic function having a dual-chamber (right atrium and right ventricle) pacemaker placed for complete heart block were studied. They performed static one-legged knee extension at 20% of their maximal voluntary contraction for 5 min during three conditions: 1) atrioventricular sensing and pacing mode [normal increase in heart rate (HR; DDD)], 2) HR fixed at the resting value (DOO-Rest; 73 \u00b1 3 beats\/min), and 3) HR fixed at peak exercise rate (DOO-Ex; 107 \u00b1 4 beats\/min). During control exercise (DDD mode), mean arterial pressure (MAP) increased by 25 mmHg with no change in stroke volume (SV) or systemic vascular resistance. During DOO-Rest and DOO-Ex, MAP increased (+25 and +29 mmHg, respectively) because of a SV-dependent increase in cardiac output (+1.3 and +1.8 l\/min, respectively). The increase in SV during DOO-Rest utilized a combination of increased contractility and the Frank-Starling mechanism (end-diastolic volume 118\u2013136 ml). However, during DOO-Ex, a greater left ventricular contractility (end-systolic volume 55\u201338 ml) mediated the increase in SV. <\/jats:p>","DOI":"10.1152\/jappl.1997.83.3.712","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T13:13:01Z","timestamp":1513948381000},"page":"712-717","source":"Crossref","is-referenced-by-count":33,"title":["Mechanisms for increasing stroke volume during static  exercise with fixed heart rate in humans"],"prefix":"10.1152","volume":"83","author":[{"given":"Antonio C. L.","family":"N\u00f3brega","sequence":"first","affiliation":[{"name":"Harry S. Moss Heart Center, University of Texas Southwestern Medical Center, Dallas, Texas 75235-9034"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon W.","family":"Williamson","sequence":"additional","affiliation":[{"name":"Harry S. 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