{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:36:39Z","timestamp":1790861799946,"version":"4.1.0"},"reference-count":24,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1997,9,1]]},"abstract":"<jats:p> Van der Meulen, Jack H., Anne McArdle, Malcolm J. Jackson, and John A. Faulkner. Contraction-induced injury to the extensor digitorum longus muscles of rats: the role of vitamin E. J. Appl. Physiol. 83(3): 817\u2013823, 1997.\u2014Three days after a protocol of 225 pliometric (lengthening) contractions was administered to in situ extensor digitorum longus muscles of rats, the force deficit was 64 \u00b1 7% and the percentage of damaged muscle fibers was 38 \u00b1 5% of the control values. We then tested the hypothesis that at 3 h and 3 days after the protocol an elevation in the muscle vitamin E content would decrease the force deficit, the percentage of damaged muscle fibers, and the serum activities of creatine kinase and pyruvate kinase. The 5\u20138 days of intravenous injections of \u03b1-tocopherol increased muscle vitamin E content threefold compared with vehicle (ethanol)-treated rats. Despite the difference in vitamin E content, the force deficit and number of damaged fibers were not different. After the contraction protocol, the serum creatine kinase and pyruvate kinase activities of the vehicle-treated rats increased fourfold at 3 h and twofold at 3 days, whereas the vitamin E-treated rats showed no change. We conclude that vitamin E treatment did not ameliorate either the induction of the injury or the more severe secondary injury at 3 days. Despite the absence of evidence for an antioxidant function, the lack of any increase in serum enzyme activities for vitamin E-treated rats at 3 h and 3 days supported a role for vitamin E in the prevention of enzyme loss after muscle damage. <\/jats:p>","DOI":"10.1152\/jappl.1997.83.3.817","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T13:13:01Z","timestamp":1513948381000},"page":"817-823","source":"Crossref","is-referenced-by-count":38,"title":["Contraction-induced injury to the extensor digitorum  longus muscles of rats: the role of vitamin E"],"prefix":"10.1152","volume":"83","author":[{"given":"Jack H.","family":"Van Der Meulen","sequence":"first","affiliation":[{"name":"Institute of Gerontology, University of Michigan, Ann Arbor, Michigan 48109-2007; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"McArdle","sequence":"additional","affiliation":[{"name":"Muscle Research Centre, Department of Medicine, University of Liverpool, Liverpool L69 3BX, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm J.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Muscle Research Centre, Department of Medicine, University of Liverpool, Liverpool L69 3BX, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Faulkner","sequence":"additional","affiliation":[{"name":"Institute of Gerontology, University of Michigan, Ann Arbor, Michigan 48109-2007; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1249\/00005768-199002000-00007","volume":"22","author":"Armstrong R. 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