{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:18:07Z","timestamp":1774916287693,"version":"3.50.1"},"reference-count":39,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1997,10,1]]},"abstract":"<jats:p>Zhang, Haibo, Peter Rogiers, Nadia Smail, Ana Cabral, Jean-Charles Preiser, Marie-Odile Peny, and Jean-Louis Vincent.Effects of nitric oxide on blood flow distribution and O<jats:sub>2<\/jats:sub>extraction capabilities during endotoxic shock. J. Appl. Physiol.83(4): 1164\u20131173, 1997.\u2014The effects of the nitric oxide (NO) synthase inhibitor N<jats:sup>G<\/jats:sup>-monomethyl-l-arginine (l-NMMA) and the NO donor 3-morpholinosydnonimine (SIN-1) were tested in 18 endotoxic dogs. l-NMMA infusion (10 mg \u22c5 kg<jats:sup>\u22121<\/jats:sup>\u22c5 h<jats:sup>\u22121<\/jats:sup>) increased arterial and pulmonary artery pressures and systemic and pulmonary vascular resistances but decreased cardiac index, left ventricular stroke work index, and blood flow to the hepatic, portal, mesenteric, and renal beds. SIN-1 infusion (2 \u03bcg \u22c5 kg<jats:sup>\u22121<\/jats:sup>\u22c5 min<jats:sup>\u22121<\/jats:sup>) increased cardiac index; left ventricular stroke work index; and hepatic, portal, and mesenteric blood flow. It did not significantly influence arterial and pulmonary artery pressures but decreased renal blood flow. The critical O<jats:sub>2<\/jats:sub>delivery was similar in thel-NMMA group and in the control group (13.3 \u00b1 1.6 vs. 12.8 \u00b1 3.3 ml \u22c5 kg<jats:sup>\u22121<\/jats:sup>\u22c5 min<jats:sup>\u22121<\/jats:sup>) but lower in the SIN-1 group (9.1 \u00b1 1.8 ml \u22c5 kg<jats:sup>\u22121<\/jats:sup>\u22c5 min<jats:sup>\u22121<\/jats:sup>, both P &lt; 0.05). The critical O<jats:sub>2<\/jats:sub>extraction ratio was also higher in the SIN-1 group than in the other groups (58.7 \u00b1 10.6 vs. 42.2 \u00b1 7.6% in controls, P &lt; 0.05; 43.0 \u00b1 15.5% inl-NMMA group, P = not significant). We conclude that NO is not implicated in the alterations in O<jats:sub>2<\/jats:sub>extraction capabilities observed early after endotoxin administration.<\/jats:p>","DOI":"10.1152\/jappl.1997.83.4.1164","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T18:35:16Z","timestamp":1513967716000},"page":"1164-1173","source":"Crossref","is-referenced-by-count":40,"title":["Effects of nitric oxide on blood flow distribution and O<sub>2<\/sub>extraction capabilities during endotoxic shock"],"prefix":"10.1152","volume":"83","author":[{"given":"Haibo","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Intensive Care, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Rogiers","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Smail","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Cabral","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Charles","family":"Preiser","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Odile","family":"Peny","sequence":"additional","affiliation":[{"name":"Department of Pathology, Erasme University Hospital, Free University of Brussels, B-1070 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Louis","family":"Vincent","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1995.78.4.1319"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199605000-00018"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(88)90073-1"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(90)94185-Z"},{"issue":"32","key":"B5","first-page":"H1963","volume":"263","author":"Brady A. 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