{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:01:03Z","timestamp":1758816063456},"reference-count":31,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1997,12,1]]},"abstract":"<jats:p>Freed, Arthur N., Varsha Taskar, Brian Schofield, and Chiharu Omori. Hyperventilation-induced airway injury and vascular leakage in dogs: effects of \u03b1<jats:sub>1<\/jats:sub>-adrenergic agonists. J. Appl. Physiol. 83(6): 1884\u20131889, 1997.\u2014\u03b1<jats:sub>1<\/jats:sub>-Adrenergic agonists inhibit hyperventilation-induced bronchoconstriction (HIB) in dogs. We tested the hypothesis that \u03b1-agonists inhibit HIB by reducing bronchovascular leakage and edema that theoretically could cause airway obstruction. Peripheral airways were isolated by using a bronchoscope; pretreated with either methoxamine (Mx), norepinephrine (NE), or saline aerosol; and then exposed to a 2,000 ml\/min dry-air challenge (DAC) for 2 min. Colloidal carbon was injected before DAC and used to quantify bronchovascular permeability. Mx-, NE-, and vehicle-treated airways were prepared for morphometric analysis within 1 h after DAC. Light microscopy revealed that the 2-min DAC produced minimal bronchovascular leakage and little epithelial damage. However, pretreatment with either Mx or NE significantly enhanced dry air-induced bronchovascular hyperpermeability and mucosal injury. The increased damage associated with these \u03b1<jats:sub>1<\/jats:sub>-agonists implicates a protective role for the bronchial circulation. The fact that \u03b1<jats:sub>1<\/jats:sub>-agonists inhibit HIB suggests that neither dry air-induced leakage nor injury directly contributes to the development of airway obstruction. In addition, our data suggest that \u03b1-agonists attenuate HIB in part by augmenting hyperventilation-induced bronchovascular leakage and by replacing airway water lost during a DAC.<\/jats:p>","DOI":"10.1152\/jappl.1997.83.6.1884","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T18:01:21Z","timestamp":1513965681000},"page":"1884-1889","source":"Crossref","is-referenced-by-count":3,"title":["Hyperventilation-induced airway injury and vascular leakage in dogs: effects of \u03b1<sub>1<\/sub>-adrenergic agonists"],"prefix":"10.1152","volume":"83","author":[{"given":"Arthur N.","family":"Freed","sequence":"first","affiliation":[{"name":"Department of Environmental Health Sciences, Division of Physiology, The Johns Hopkins University, Baltimore, Maryland 21205; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varsha","family":"Taskar","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, Division of Physiology, The Johns Hopkins University, Baltimore, Maryland 21205; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Schofield","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, Division of Physiology, The Johns Hopkins University, Baltimore, Maryland 21205; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiharu","family":"Omori","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Nihon University School of Medicine, Tokyo, 173 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","first-page":"459","volume":"63","author":"Anderson S. 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