{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T01:36:12Z","timestamp":1774661772200,"version":"3.50.1"},"reference-count":27,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1997,12,1]]},"abstract":"<jats:p> Carley, David W., Sinisa M. Trbovic, Alex Bozanich, and Miodrag Radulovacki. Cardiopulmonary control in sleeping Sprague-Dawley rats treated with hydralazine. J. Appl. Physiol. 83(6): 1954\u20131961, 1997.\u2014To test the hypothesis that hydralazine can suppress spontaneous sleep-related central apnea, respiratory pattern, blood pressure, and heart period were monitored in Sprague-Dawley rats. In random order and on separate days, rats were recorded after intraperitoneal injection of 1) saline or 2) 2 mg\/kg hydralazine. Normalized minute ventilation (NV\u02d9i) declined significantly with transitions from wake to non-rapid-eye-movement (NREM) sleep (\u22125.1%; P = 0.01) and rapid-eye-movement (REM) sleep (\u22124.2%; P = 0.022). Hydralazine stimulated respiration (NV\u02d9iincreased by 21%; P &lt; 0.03) and eliminated the effect of state on NV\u02d9i. Blood pressure decreased by 17% after hydralazine, and the correlation between fluctuations in mean blood pressure and NV\u02d9i changed from strongly positive during control recordings to weakly negative after hydralazine ( P &lt; 0.0001 for each). Postsigh and spontaneous apneas were reduced during NREM and REM sleep after hydralazine ( P &lt; 0.05 for each). This suppression was strongly correlated with the reduction in blood pressure and with the degree of respiratory stimulation. We conclude that mild hydralazine-induced hypotension leads to respiratory stimulation and apnea suppression. <\/jats:p>","DOI":"10.1152\/jappl.1997.83.6.1954","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T13:01:21Z","timestamp":1513947681000},"page":"1954-1961","source":"Crossref","is-referenced-by-count":12,"title":["Cardiopulmonary control in sleeping Sprague-Dawley  rats treated with hydralazine"],"prefix":"10.1152","volume":"83","author":[{"given":"David W.","family":"Carley","sequence":"first","affiliation":[{"name":"Section of Respiratory and Critical Care Medicine and"},{"name":"Department of Pharmacology, University of Illinois College of Medicine at Chicago, Chicago, Illinois 60612"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinisa M.","family":"Trbovic","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Illinois College of Medicine at Chicago, Chicago, Illinois 60612"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Bozanich","sequence":"additional","affiliation":[{"name":"Section of Respiratory and Critical Care Medicine and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miodrag","family":"Radulovacki","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Illinois College of Medicine at Chicago, Chicago, Illinois 60612"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/17.1.28"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/19.5.363"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(95)02205-8"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.80.6.2102"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1980.49.6.1107"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-103-2-190"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1975.39.3.411"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1991.00400030025005"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1159\/000174864"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199100411-00008"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1983.128.3.429"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(88)90243-0"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1378\/chest.99.4.861"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(95)02032-2"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1992.73.4.1549"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1996.76.1.193"},{"key":"B19","first-page":"909","volume":"118","author":"Phillipson E.","year":"1978","journal-title":"Am. 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