{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T07:22:15Z","timestamp":1792826535060,"version":"4.5.0"},"reference-count":13,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1998,1,1]]},"abstract":"<jats:p> O\u2019Brien, Catherine, Andrew J. Young, and Michael N. Sawka.Hypohydration and thermoregulation in cold air. J. Appl. Physiol. 84(1): 185\u2013189, 1998.\u2014This study examined the effects of hypohydration on thermoregulation during cold exposure. In addition, the independent influences of hypohydration-associated hypertonicity and hypovolemia were investigated. Nine male volunteers were monitored for 30 min at 25\u00b0C, then for 120 min at 7\u00b0C, under three counterbalanced conditions: euhydration (Eu), hypertonic hypohydration (HH), and isotonic hypohydration (IH). Hypohydration was achieved 12 h before cold exposure by inducing sweating (HH) or by ingestion of furosemide (IH). Body weight decrease (4.1 \u00b1 0.2%) caused by hypohydration was similar for HH and IH, but differences ( P &lt; 0.05) were found between HH and IH in plasma osmolality (292 \u00b1 1 vs. 284 \u00b1 1 mosmol\/kgH<jats:sub>2<\/jats:sub>O) and plasma volume reduction (\u22128 \u00b1 2 vs. \u221218 \u00b1 3%). Heat debt (349 \u00b1 14 among) did not differ ( P &gt; 0.05) among trials. Mean skin temperature decreased throughout cold exposure during Eu but plateaued after 90 min during HH and IH. Forearm-finger temperature gradient tended ( P = 0.06) to be greater during Eu (10.0 \u00b1 0.7\u00b0C) than during HH or IH (8.9 \u00b1 0.7\u00b0C). This suggests weaker vasoconstrictor tone during hypohydration than during Eu. Final mean skin temperature was higher for HH than for Eu or IH (23.5 \u00b1 0.3, 22.6 \u00b1 0.4, and 22.9 \u00b1 0.3\u00b0C, respectively), and insulation was lower on HH than on IH (0.13 \u00b1 0.01 vs. 0.15 \u00b1 0.01\u00b0C \u22c5 W<jats:sup>\u22121<\/jats:sup> \u22c5 m<jats:sup>\u22122<\/jats:sup>, respectively), but not with Eu (0.14 \u00b1 0.01\u00b0C \u22c5 W<jats:sup>\u22121<\/jats:sup> \u22c5 m<jats:sup>\u22122<\/jats:sup>). This provides some evidence that hypertonicity impairs the vasoconstrictor response to cold. Although mild hypohydration did not affect body heat balance during 2-h whole body exposure to moderate cold, hypohydration-associated hypertonicity may have subtle effects on vasoconstriction that could become important during a more severe cold exposure. <\/jats:p>","DOI":"10.1152\/jappl.1998.84.1.185","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T19:31:46Z","timestamp":1513971106000},"page":"185-189","source":"Crossref","is-referenced-by-count":49,"title":["Hypohydration and thermoregulation in cold air"],"prefix":"10.1152","volume":"84","author":[{"given":"Catherine","family":"O\u2019Brien","sequence":"first","affiliation":[{"name":"United States Army Research Institute of Environmental Medicine, Natick, Massachusetts 01760"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Young","sequence":"additional","affiliation":[{"name":"United States Army Research Institute of Environmental Medicine, Natick, Massachusetts 01760"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael N.","family":"Sawka","sequence":"additional","affiliation":[{"name":"United States Army Research Institute of Environmental Medicine, Natick, Massachusetts 01760"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1987.62.4.1627"},{"key":"B2","first-page":"2843","volume":"40","author":"Boulant J. A.","year":"1981","journal-title":"Federation Proc."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1977.tb38195.x"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1974.37.2.247"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/55.4.764"},{"key":"B9","first-page":"A116","volume":"10","author":"Lee D. T.","year":"1996","journal-title":"FASEB J."},{"key":"B11","first-page":"177","volume":"15","author":"Lewis T.","year":"1930","journal-title":"Heart"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1995.79.5.1434"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1970.29.6.830"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1093\/milmed\/153.12.605"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199206000-00008"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199204000-00009"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1992.72.4.1380"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1998.84.1.185","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T18:51:32Z","timestamp":1567968692000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1998.84.1.185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,1,1]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1998,1,1]]}},"alternative-id":["10.1152\/jappl.1998.84.1.185"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1998.84.1.185","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,1,1]]}}}