{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T03:38:59Z","timestamp":1773459539780,"version":"3.50.1"},"reference-count":37,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1998,1,1]]},"abstract":"<jats:p>Iturriaga, Rodrigo, and Julio Alcayaga. Effects of CO<jats:sub>2<\/jats:sub>-[Formula: see text]on catecholamine efflux from cat carotid body. J. Appl. Physiol. 84(1): 60\u201368, 1998.\u2014Using a chronoamperometric technique with carbon-fiber microelectrodes and neural recordings, we simultaneously measured the effects of the following procedures on catecholamine efflux (\u0394CA) and frequency of chemosensory discharges ( f<jats:sub>x<\/jats:sub>) from superfused cat carotid body: 1) the addition of CO<jats:sub>2<\/jats:sub>-[Formula: see text]to Tyrode solution previously buffered with N-2-hydroxyethylpiperazine- N\u2032 -2-ethanesulfonic acid, maintaining pH at 7.40; 2) hypercapnia (10% CO<jats:sub>2<\/jats:sub>, pH 7.10); 3) hypoxia ([Formula: see text] h\u2009\u2248\u200940 Torr) with and without CO<jats:sub>2<\/jats:sub>-[Formula: see text]; and 4) the impact of several boluses of dopamine (DA; 10\u2013100 \u03bcg) on hypoxic and hypercapnic challenges. With CO<jats:sub>2<\/jats:sub>-[Formula: see text], hypoxia increased f<jats:sub>x<\/jats:sub>which preceded \u0394CA increases, whereas hypercapnia raised f<jats:sub>x<\/jats:sub>but did not consistently increase \u0394CA. Repeated stimuli induced similar f<jats:sub>x<\/jats:sub>increases, but attenuated \u0394CA. After DA, hypoxia produced larger \u0394CA, which preceded chemosensory responses. Without CO<jats:sub>2<\/jats:sub>-[Formula: see text], hypoxia produced a similar pattern of \u0394CA and f<jats:sub>x<\/jats:sub>responses. Switching to Tyrode solution with CO<jats:sub>2<\/jats:sub>-[Formula: see text]at pH 7.40 raised f<jats:sub>x<\/jats:sub>but did not increase \u0394CA. With CO<jats:sub>2<\/jats:sub>-[Formula: see text]and after DA, hypoxic-induced \u0394CAs were larger than in its absence. 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