{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T22:57:08Z","timestamp":1774565828479,"version":"3.50.1"},"reference-count":31,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1998,2,1]]},"abstract":"<jats:p>Doe, S., and A. M. Perks. \u03b1-Adrenoreceptor influences on liquid movements by in vitro lungs from fetal guinea pigs. J. Appl. Physiol. 84(2): 746\u2013753, 1998.\u2014Lungs from near-term fetal guinea pigs (60 \u00b1 2 days of gestation) were supported in vitro for 3 h; lung liquid production was monitored by a dye-dilution method. Studies of 30 fetuses showed that untreated preparations produced fluid at 1.34 \u00b1 0.21 ml \u22c5 h<jats:sup>\u22121<\/jats:sup>\u22c5 kg body wt<jats:sup>\u22121<\/jats:sup>, but epinephrine at concentrations known at delivery (10<jats:sup>\u22128<\/jats:sup>and 10<jats:sup>\u22127<\/jats:sup>M) produced significant reductions or fluid reabsorption (analysis of variance, regression analysis); at high levels (10<jats:sup>\u22126<\/jats:sup>and 10<jats:sup>\u22125<\/jats:sup>M), epinephrine had no effect. Maximal responses from 10<jats:sup>\u22127<\/jats:sup>M epinephrine involved \u03b1-adrenoreceptors, since they were abolished by 10<jats:sup>\u22126<\/jats:sup>M phentolamine (\u03b1-antagonist) but were unaffected by 10<jats:sup>\u22126<\/jats:sup>M propranolol (\u03b2-antagonist; n = 36). Activation was through \u03b1<jats:sub>2<\/jats:sub>-adrenoreceptors, since responses were abolished by 10<jats:sup>\u22124<\/jats:sup>M yohimbine (\u03b1<jats:sub>2<\/jats:sub>-antagonist; n = 24) but were resistant to 10<jats:sup>\u22125<\/jats:sup>M prazosin (\u03b1<jats:sub>1<\/jats:sub>-antagonist; n = 24). At high levels of epinephrine (10<jats:sup>\u22125<\/jats:sup>M), where responses did not normally occur, reductions in lung liquid production were large if prazosin was also present ( n = 24), and increases were significant if yohimbine was included ( n = 24). In guinea pigs, epinephrine appears to activate lung fluid reabsorption through \u03b1<jats:sub>2<\/jats:sub>-adrenoreceptors; at high concentrations only, it can also increase production through \u03b1<jats:sub>1<\/jats:sub>-adrenoreceptors. 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