{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T12:39:13Z","timestamp":1762000753663,"version":"build-2065373602"},"reference-count":32,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1998,8,1]]},"abstract":"<jats:p> Diffusional permeability ( P) to sucrose ( P <jats:sub>suc<\/jats:sub>) and Na<jats:sup>+<\/jats:sup>([Formula: see text]) was determined in specimens of rabbit sternal parietal pericardium, which may be obtained without stripping. Specimens were mounted in an Ussing apparatus with <jats:sup>3<\/jats:sup>H-labeled sucrose and<jats:sup>22<\/jats:sup>Na<jats:sup>+<\/jats:sup>in a luminal (L) or interstitial (I) chamber. P <jats:sub>suc<\/jats:sub> was 2.16 \u00b1 0.44 for L\u2192I and 2.63 \u00b1 0.45 (SE) \u00d7 10<jats:sup>\u22125<\/jats:sup> cm\/s for I\u2192L, i.e., \u223c10 times smaller than that previously obtained in stripped specimens of pleura despite the similarity of intercellular junctions in pericardium and pleural mesothelium of various species. These findings suggest that previous P <jats:sub>suc<\/jats:sub> was overestimated because stripping damages the mesothelium.[Formula: see text](\u00d710<jats:sup>\u22125<\/jats:sup> cm\/s) was 7.07 \u00b1 0.71 for L\u2192I and 7.37 \u00b1 0.69 \u00d7 10<jats:sup>\u22125<\/jats:sup> cm\/s for I\u2192L. Measurements were also done with phospholipids, which are adsorbed on the luminal side of mesothelium in vivo. With phospholipids in L, P <jats:sub>suc<\/jats:sub> was 0.75 \u00b1 0.10 and 0.65 \u00b1 0.08 and[Formula: see text]was 3.80 \u00b1 0.32 and 3.76 \u00b1 0.15 \u00d7 10<jats:sup>\u22125<\/jats:sup> cm\/s for L\u2192I and I\u2192L, respectively, i.e., smaller than without phospholipids. With phospholipids in I (where they are not adsorbed), P <jats:sub>suc<\/jats:sub> (2.33 \u00b1 0.42 \u00d7 10<jats:sup>\u22125<\/jats:sup> cm\/s) and[Formula: see text](7.01 \u00b1 0.45 \u00d7 10<jats:sup>\u22125<\/jats:sup> cm\/s) were similar to those values without phospholipids. Hence, adsorbed phospholipids decrease P of mesothelium. If the mesothelium were scraped away from the specimen, P <jats:sub>suc<\/jats:sub> of the connective tissue would be 13.2 \u00b1 0.76 \u00d7 10<jats:sup>\u22125<\/jats:sup> cm\/s. P <jats:sub>suc<\/jats:sub> of the mesothelium, computed from P <jats:sub>suc<\/jats:sub> of the unscraped and scraped specimens, corrected for the effect of unstirred layers (2.54 and 19.4 \u00d7 10<jats:sup>\u22125<\/jats:sup> cm\/s, respectively), was 2.92 and 0.74 \u00d7 10<jats:sup>\u22125<\/jats:sup> cm\/s without and with phospholipids, respectively. Hence, most of the resistance to diffusion of the pericardium is provided by the mesothelium. <\/jats:p>","DOI":"10.1152\/jappl.1998.85.2.471","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T20:55:50Z","timestamp":1513976150000},"page":"471-477","source":"Crossref","is-referenced-by-count":18,"title":["Diffusional permeability of rabbit mesothelium"],"prefix":"10.1152","volume":"85","author":[{"given":"L.","family":"Zocchi","sequence":"first","affiliation":[{"name":"Istituto di Fisiologia Umana I and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Raffaini","sequence":"additional","affiliation":[{"name":"Istituto di Fisiologia Umana I and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Agostoni","sequence":"additional","affiliation":[{"name":"Istituto di Fisiologia Umana I and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Cremaschi","sequence":"additional","affiliation":[{"name":"Dipartimento di Fisiologia e Biochimica Generali, Universit\u00e0 di Milano, 20133 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(93)90123-R"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001650305"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1984.64.3.763"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.71.2.195"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1926.6.2.242"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.59.4.367"},{"key":"B8","first-page":"53","volume":"18","author":"Fentie I. 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