{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:15:45Z","timestamp":1790511345241,"version":"4.1.0"},"reference-count":25,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1998,9,1]]},"abstract":"<jats:p>Whether nitric oxide (NO) is involved in cutaneous active vasodilation during hyperthermia in humans is unclear. We tested for a role of NO in this process during heat stress (water-perfused suits) in seven healthy subjects. Two forearm sites were instrumented with intradermal microdialysis probes. One site was perfused with the NO synthase inhibitor N<jats:sup>G<\/jats:sup>-nitro-l-arginine methyl ester (l-NAME) dissolved in Ringer solution to abolish NO production. The other site was perfused with Ringer solution only. At those sites, skin blood flow (laser-Doppler flowmetry) and sweat rate were simultaneously and continuously monitored. Cutaneous vascular conductance, calculated from laser-Doppler flowmetry and mean arterial pressure, was normalized to maximal levels as achieved by perfusion with the NO donor nitroprusside through the microdialysis probes. Under normothermic conditions,l-NAME did not significantly reduce cutaneous vascular conductance. During hyperthermia, with skin temperature held at 38\u201338.5\u00b0C, internal temperature rose from 36.66 \u00b1 0.10 to 37.34 \u00b1 0.06\u00b0C ( P &lt; 0.01). Cutaneous vascular conductance at untreated sites increased from 12 \u00b1 2 to 44 \u00b1 5% of maximum, but only rose from 13 \u00b1 2 to 30 \u00b1 5% of maximum at l-NAME-treated sites ( P &lt; 0.05 between sites) during heat stress. l-NAME had no effect on sweat rate ( P &gt; 0.05). Thus cutaneous active vasodilation requires functional NO synthase to achieve full expression.<\/jats:p>","DOI":"10.1152\/jappl.1998.85.3.824","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T20:48:13Z","timestamp":1513975693000},"page":"824-829","source":"Crossref","is-referenced-by-count":261,"title":["Nitric oxide and cutaneous active vasodilation during heat stress in humans"],"prefix":"10.1152","volume":"85","author":[{"suffix":"Jr.","given":"D. L.","family":"Kellogg","sequence":"first","affiliation":[{"name":"Geriatric Research, Education, and Clinical Center, Department of Veterans Affairs, South Texas Veterans Health Care System, Audie L. Murphy Division, San Antonio 78284; Departments of"},{"name":"Physiology,"},{"name":"Medicine, and"},{"name":"Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, 78284;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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