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NE administration in CB-intact goats caused dose-dependent inhibition of PNA of similar magnitude to DA trials. The DA D<jats:sub>2<\/jats:sub>-receptor agonists quinelorane and quinpirole inhibited PNA, whereas the DA D<jats:sub>1<\/jats:sub>-receptor agonist SKF-81297 had no effect. After CBD, the ventilatory depressant effects of DA persisted, but responses were significantly attenuated compared with CB-intact trials. CBD abolished the inhibitory effect of low-dose NE administration but did not alter ventilatory responses to high-dose NE injection. The peripheral DA D<jats:sub>2<\/jats:sub>-receptor antagonist domperidone substantially attenuated the inhibitory effects of DA bolus injections and infusions and reversed the inhibitory ventilatory effect of high-dose DA administration to excitation in some animals. The \u03b1-adrenoceptor antagonist phentolamine had no effect on DA-induced ventilatory depression. \u03b2-Adrenoceptor stimulation with isoproterenol produced similar hemodynamic effects to DA administration but had no effect on PNA. We conclude that DA and NE exert both CB-mediated and non-CB-mediated inhibitory effects on respiratory motor output in anesthetized goats. The ventilatory depressant effects that persist in peripherally chemodenervated animals are DA D<jats:sub>2<\/jats:sub>-receptor mediated, but their exact location remains speculative.<\/jats:p>","DOI":"10.1152\/jappl.1998.85.3.946","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T20:48:13Z","timestamp":1513975693000},"page":"946-954","source":"Crossref","is-referenced-by-count":13,"title":["Dopaminergic modulation of respiratory motor output in peripherally chemodenervated goats"],"prefix":"10.1152","volume":"85","author":[{"given":"Ken D.","family":"O\u2019Halloran","sequence":"first","affiliation":[{"name":"Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53706"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick L.","family":"Janssen","sequence":"additional","affiliation":[{"name":"Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53706"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald E.","family":"Bisgard","sequence":"additional","affiliation":[{"name":"Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53706"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00501387"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(80)90036-5"},{"key":"B3","first-page":"A297","volume":"155","author":"Bisgard G. 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